Three-quarters attack rate of SARS-CoV-2 in the Brazilian Amazon during a largely unmitigated epidemic

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly in Manaus, the capital of Amazonas state in northern Brazil. The attack rate there is an estimate of the final size of the largely unmitigated epidemic that occurred in Manaus. We use a convenience sample of blood donors to...

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Autores principales: Buss, Lewis F., Prete, Carlos A., Abrahim, Claudia M. M., Mendrone, Alfredo, Salomon, Tassila, de Almeida-Neto, Cesar, França, Rafael F. O., Belotti, Maria C., Carvalho, Maria P. S. S., Costa, Allyson G., Crispim, Myuki A. E., Ferreira, Suzete C., Fraiji, Nelson A., Gurzenda, Susie, Whittaker, Charles, Kamaura, Leonardo T., Takecian, Pedro L., da Silva Peixoto, Pedro, Oikawa, Marcio K., Nishiya, Anna S., Rocha, Vanderson, Salles, Nanci A., de Souza Santos, Andreza Aruska, da Silva, Martirene A., Custer, Brian, Parag, Kris V., Barral-Netto, Manoel, Kraemer, Moritz U. G., Pereira, Rafael H. M., Pybus, Oliver G., Busch, Michael P., Castro, Márcia C., Dye, Christopher, Nascimento, Vítor H., Faria, Nuno R., Sabino, Ester C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857406/
https://www.ncbi.nlm.nih.gov/pubmed/33293339
http://dx.doi.org/10.1126/science.abe9728
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author Buss, Lewis F.
Prete, Carlos A.
Abrahim, Claudia M. M.
Mendrone, Alfredo
Salomon, Tassila
de Almeida-Neto, Cesar
França, Rafael F. O.
Belotti, Maria C.
Carvalho, Maria P. S. S.
Costa, Allyson G.
Crispim, Myuki A. E.
Ferreira, Suzete C.
Fraiji, Nelson A.
Gurzenda, Susie
Whittaker, Charles
Kamaura, Leonardo T.
Takecian, Pedro L.
da Silva Peixoto, Pedro
Oikawa, Marcio K.
Nishiya, Anna S.
Rocha, Vanderson
Salles, Nanci A.
de Souza Santos, Andreza Aruska
da Silva, Martirene A.
Custer, Brian
Parag, Kris V.
Barral-Netto, Manoel
Kraemer, Moritz U. G.
Pereira, Rafael H. M.
Pybus, Oliver G.
Busch, Michael P.
Castro, Márcia C.
Dye, Christopher
Nascimento, Vítor H.
Faria, Nuno R.
Sabino, Ester C.
author_facet Buss, Lewis F.
Prete, Carlos A.
Abrahim, Claudia M. M.
Mendrone, Alfredo
Salomon, Tassila
de Almeida-Neto, Cesar
França, Rafael F. O.
Belotti, Maria C.
Carvalho, Maria P. S. S.
Costa, Allyson G.
Crispim, Myuki A. E.
Ferreira, Suzete C.
Fraiji, Nelson A.
Gurzenda, Susie
Whittaker, Charles
Kamaura, Leonardo T.
Takecian, Pedro L.
da Silva Peixoto, Pedro
Oikawa, Marcio K.
Nishiya, Anna S.
Rocha, Vanderson
Salles, Nanci A.
de Souza Santos, Andreza Aruska
da Silva, Martirene A.
Custer, Brian
Parag, Kris V.
Barral-Netto, Manoel
Kraemer, Moritz U. G.
Pereira, Rafael H. M.
Pybus, Oliver G.
Busch, Michael P.
Castro, Márcia C.
Dye, Christopher
Nascimento, Vítor H.
Faria, Nuno R.
Sabino, Ester C.
author_sort Buss, Lewis F.
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly in Manaus, the capital of Amazonas state in northern Brazil. The attack rate there is an estimate of the final size of the largely unmitigated epidemic that occurred in Manaus. We use a convenience sample of blood donors to show that by June 2020, 1 month after the epidemic peak in Manaus, 44% of the population had detectable immunoglobulin G (IgG) antibodies. Correcting for cases without a detectable antibody response and for antibody waning, we estimate a 66% attack rate in June, rising to 76% in October. This is higher than in São Paulo, in southeastern Brazil, where the estimated attack rate in October was 29%. These results confirm that when poorly controlled, COVID-19 can infect a large proportion of the population, causing high mortality.
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spelling pubmed-78574062021-02-05 Three-quarters attack rate of SARS-CoV-2 in the Brazilian Amazon during a largely unmitigated epidemic Buss, Lewis F. Prete, Carlos A. Abrahim, Claudia M. M. Mendrone, Alfredo Salomon, Tassila de Almeida-Neto, Cesar França, Rafael F. O. Belotti, Maria C. Carvalho, Maria P. S. S. Costa, Allyson G. Crispim, Myuki A. E. Ferreira, Suzete C. Fraiji, Nelson A. Gurzenda, Susie Whittaker, Charles Kamaura, Leonardo T. Takecian, Pedro L. da Silva Peixoto, Pedro Oikawa, Marcio K. Nishiya, Anna S. Rocha, Vanderson Salles, Nanci A. de Souza Santos, Andreza Aruska da Silva, Martirene A. Custer, Brian Parag, Kris V. Barral-Netto, Manoel Kraemer, Moritz U. G. Pereira, Rafael H. M. Pybus, Oliver G. Busch, Michael P. Castro, Márcia C. Dye, Christopher Nascimento, Vítor H. Faria, Nuno R. Sabino, Ester C. Science Reports Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly in Manaus, the capital of Amazonas state in northern Brazil. The attack rate there is an estimate of the final size of the largely unmitigated epidemic that occurred in Manaus. We use a convenience sample of blood donors to show that by June 2020, 1 month after the epidemic peak in Manaus, 44% of the population had detectable immunoglobulin G (IgG) antibodies. Correcting for cases without a detectable antibody response and for antibody waning, we estimate a 66% attack rate in June, rising to 76% in October. This is higher than in São Paulo, in southeastern Brazil, where the estimated attack rate in October was 29%. These results confirm that when poorly controlled, COVID-19 can infect a large proportion of the population, causing high mortality. American Association for the Advancement of Science 2021-01-15 2020-12-08 /pmc/articles/PMC7857406/ /pubmed/33293339 http://dx.doi.org/10.1126/science.abe9728 Text en Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reports
Buss, Lewis F.
Prete, Carlos A.
Abrahim, Claudia M. M.
Mendrone, Alfredo
Salomon, Tassila
de Almeida-Neto, Cesar
França, Rafael F. O.
Belotti, Maria C.
Carvalho, Maria P. S. S.
Costa, Allyson G.
Crispim, Myuki A. E.
Ferreira, Suzete C.
Fraiji, Nelson A.
Gurzenda, Susie
Whittaker, Charles
Kamaura, Leonardo T.
Takecian, Pedro L.
da Silva Peixoto, Pedro
Oikawa, Marcio K.
Nishiya, Anna S.
Rocha, Vanderson
Salles, Nanci A.
de Souza Santos, Andreza Aruska
da Silva, Martirene A.
Custer, Brian
Parag, Kris V.
Barral-Netto, Manoel
Kraemer, Moritz U. G.
Pereira, Rafael H. M.
Pybus, Oliver G.
Busch, Michael P.
Castro, Márcia C.
Dye, Christopher
Nascimento, Vítor H.
Faria, Nuno R.
Sabino, Ester C.
Three-quarters attack rate of SARS-CoV-2 in the Brazilian Amazon during a largely unmitigated epidemic
title Three-quarters attack rate of SARS-CoV-2 in the Brazilian Amazon during a largely unmitigated epidemic
title_full Three-quarters attack rate of SARS-CoV-2 in the Brazilian Amazon during a largely unmitigated epidemic
title_fullStr Three-quarters attack rate of SARS-CoV-2 in the Brazilian Amazon during a largely unmitigated epidemic
title_full_unstemmed Three-quarters attack rate of SARS-CoV-2 in the Brazilian Amazon during a largely unmitigated epidemic
title_short Three-quarters attack rate of SARS-CoV-2 in the Brazilian Amazon during a largely unmitigated epidemic
title_sort three-quarters attack rate of sars-cov-2 in the brazilian amazon during a largely unmitigated epidemic
topic Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857406/
https://www.ncbi.nlm.nih.gov/pubmed/33293339
http://dx.doi.org/10.1126/science.abe9728
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