Cargando…
Factors associated with under-reporting of head and neck squamous cell carcinoma in cause-of-death records: A comparative study of two national databases in France from 2008 to 2012
OBJECTIVE: To date, no study has evaluated the detection rate of head and neck squamous cell carcinoma (HNSCC) in cause-of-death records in Europe. Our objectives were to compare the number of deaths attributable to HNSCC from two national databases in France and to identify factors associated with...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857613/ https://www.ncbi.nlm.nih.gov/pubmed/33534860 http://dx.doi.org/10.1371/journal.pone.0246252 |
_version_ | 1783646477843693568 |
---|---|
author | Even, Caroline Sagaon Teyssier, Luis Pointreau, Yoann Temam, Stéphane Huguet, Florence Geoffrois, Lionnel Schwarzinger, Michaël |
author_facet | Even, Caroline Sagaon Teyssier, Luis Pointreau, Yoann Temam, Stéphane Huguet, Florence Geoffrois, Lionnel Schwarzinger, Michaël |
author_sort | Even, Caroline |
collection | PubMed |
description | OBJECTIVE: To date, no study has evaluated the detection rate of head and neck squamous cell carcinoma (HNSCC) in cause-of-death records in Europe. Our objectives were to compare the number of deaths attributable to HNSCC from two national databases in France and to identify factors associated with under-reporting of HNSCC in cause-of-death records. METHODS: The national hospital discharge database and the national underlying cause-of-death records were compared for all HNSCC-attributable deaths in adult patients from 2008 to 2012 in France. Factors associated with under-reporting of HNSCC in cause-of-death records were assessed using multivariate Poisson regression. RESULTS: A total of 41,503 in-hospital deaths were attributable to HNSCC as compared to 25,647 deaths reported in national UCoD records (a detection rate of 62%). Demographics at death were similar in both databases with respect to gender (83% men), age (54% premature deaths at 25–64 years), and geographic distribution. In multivariate Poisson regression, under-reporting of HNSCC in cause-of-death records significantly increased in 2012 compared to 2010 (+7%) and was independently associated with a primary HNSCC site other than the larynx, a former primary or second synchronous cancer other than HNSCC, distant metastasis, palliative care, and death in hospitals other than comprehensive cancer care centers. The main study results were robust in a sensitivity analysis which also took into account deaths outside hospital (overall, 51,129 HNSCC-attributable deaths; a detection rate of 50%). For the year 2012, the age-standardized mortality rate for HNSCC derived from underlying cause-of-death records was less than half that derived from hospital discharge summaries (14.7 compared to 34.1 per 100,000 for men and 2.7 compared to 6.2 per 100,000 for women). CONCLUSION: HNSCC is largely under-reported in cause-of-death records. This study documents the value of national hospital discharge databases as a complement to death certificates for ascertaining cancer deaths. |
format | Online Article Text |
id | pubmed-7857613 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-78576132021-02-11 Factors associated with under-reporting of head and neck squamous cell carcinoma in cause-of-death records: A comparative study of two national databases in France from 2008 to 2012 Even, Caroline Sagaon Teyssier, Luis Pointreau, Yoann Temam, Stéphane Huguet, Florence Geoffrois, Lionnel Schwarzinger, Michaël PLoS One Research Article OBJECTIVE: To date, no study has evaluated the detection rate of head and neck squamous cell carcinoma (HNSCC) in cause-of-death records in Europe. Our objectives were to compare the number of deaths attributable to HNSCC from two national databases in France and to identify factors associated with under-reporting of HNSCC in cause-of-death records. METHODS: The national hospital discharge database and the national underlying cause-of-death records were compared for all HNSCC-attributable deaths in adult patients from 2008 to 2012 in France. Factors associated with under-reporting of HNSCC in cause-of-death records were assessed using multivariate Poisson regression. RESULTS: A total of 41,503 in-hospital deaths were attributable to HNSCC as compared to 25,647 deaths reported in national UCoD records (a detection rate of 62%). Demographics at death were similar in both databases with respect to gender (83% men), age (54% premature deaths at 25–64 years), and geographic distribution. In multivariate Poisson regression, under-reporting of HNSCC in cause-of-death records significantly increased in 2012 compared to 2010 (+7%) and was independently associated with a primary HNSCC site other than the larynx, a former primary or second synchronous cancer other than HNSCC, distant metastasis, palliative care, and death in hospitals other than comprehensive cancer care centers. The main study results were robust in a sensitivity analysis which also took into account deaths outside hospital (overall, 51,129 HNSCC-attributable deaths; a detection rate of 50%). For the year 2012, the age-standardized mortality rate for HNSCC derived from underlying cause-of-death records was less than half that derived from hospital discharge summaries (14.7 compared to 34.1 per 100,000 for men and 2.7 compared to 6.2 per 100,000 for women). CONCLUSION: HNSCC is largely under-reported in cause-of-death records. This study documents the value of national hospital discharge databases as a complement to death certificates for ascertaining cancer deaths. Public Library of Science 2021-02-03 /pmc/articles/PMC7857613/ /pubmed/33534860 http://dx.doi.org/10.1371/journal.pone.0246252 Text en © 2021 Even et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Even, Caroline Sagaon Teyssier, Luis Pointreau, Yoann Temam, Stéphane Huguet, Florence Geoffrois, Lionnel Schwarzinger, Michaël Factors associated with under-reporting of head and neck squamous cell carcinoma in cause-of-death records: A comparative study of two national databases in France from 2008 to 2012 |
title | Factors associated with under-reporting of head and neck squamous cell carcinoma in cause-of-death records: A comparative study of two national databases in France from 2008 to 2012 |
title_full | Factors associated with under-reporting of head and neck squamous cell carcinoma in cause-of-death records: A comparative study of two national databases in France from 2008 to 2012 |
title_fullStr | Factors associated with under-reporting of head and neck squamous cell carcinoma in cause-of-death records: A comparative study of two national databases in France from 2008 to 2012 |
title_full_unstemmed | Factors associated with under-reporting of head and neck squamous cell carcinoma in cause-of-death records: A comparative study of two national databases in France from 2008 to 2012 |
title_short | Factors associated with under-reporting of head and neck squamous cell carcinoma in cause-of-death records: A comparative study of two national databases in France from 2008 to 2012 |
title_sort | factors associated with under-reporting of head and neck squamous cell carcinoma in cause-of-death records: a comparative study of two national databases in france from 2008 to 2012 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857613/ https://www.ncbi.nlm.nih.gov/pubmed/33534860 http://dx.doi.org/10.1371/journal.pone.0246252 |
work_keys_str_mv | AT evencaroline factorsassociatedwithunderreportingofheadandnecksquamouscellcarcinomaincauseofdeathrecordsacomparativestudyoftwonationaldatabasesinfrancefrom2008to2012 AT sagaonteyssierluis factorsassociatedwithunderreportingofheadandnecksquamouscellcarcinomaincauseofdeathrecordsacomparativestudyoftwonationaldatabasesinfrancefrom2008to2012 AT pointreauyoann factorsassociatedwithunderreportingofheadandnecksquamouscellcarcinomaincauseofdeathrecordsacomparativestudyoftwonationaldatabasesinfrancefrom2008to2012 AT temamstephane factorsassociatedwithunderreportingofheadandnecksquamouscellcarcinomaincauseofdeathrecordsacomparativestudyoftwonationaldatabasesinfrancefrom2008to2012 AT huguetflorence factorsassociatedwithunderreportingofheadandnecksquamouscellcarcinomaincauseofdeathrecordsacomparativestudyoftwonationaldatabasesinfrancefrom2008to2012 AT geoffroislionnel factorsassociatedwithunderreportingofheadandnecksquamouscellcarcinomaincauseofdeathrecordsacomparativestudyoftwonationaldatabasesinfrancefrom2008to2012 AT schwarzingermichael factorsassociatedwithunderreportingofheadandnecksquamouscellcarcinomaincauseofdeathrecordsacomparativestudyoftwonationaldatabasesinfrancefrom2008to2012 AT factorsassociatedwithunderreportingofheadandnecksquamouscellcarcinomaincauseofdeathrecordsacomparativestudyoftwonationaldatabasesinfrancefrom2008to2012 |