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Scalable representation of time in the hippocampus
Hippocampal “time cells” encode specific moments of temporally organized experiences that may support hippocampal functions for episodic memory. However, little is known about the reorganization of the temporal representation of time cells during changes in temporal structures of episodes. We invest...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American Association for the Advancement of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857679/ https://www.ncbi.nlm.nih.gov/pubmed/33536211 http://dx.doi.org/10.1126/sciadv.abd7013 |
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author | Shimbo, Akihiro Izawa, Ei-Ichi Fujisawa, Shigeyoshi |
author_facet | Shimbo, Akihiro Izawa, Ei-Ichi Fujisawa, Shigeyoshi |
author_sort | Shimbo, Akihiro |
collection | PubMed |
description | Hippocampal “time cells” encode specific moments of temporally organized experiences that may support hippocampal functions for episodic memory. However, little is known about the reorganization of the temporal representation of time cells during changes in temporal structures of episodes. We investigated CA1 neuronal activity during temporal bisection tasks, in which the sets of time intervals to be discriminated were designed to be extended or contracted across the blocks of trials. Assemblies of neurons encoded elapsed time during the interval, and the representation was scaled when the set of interval times was varied. Theta phase precession and theta sequences of time cells were also scalable, and the fine temporal relationships were preserved between pairs in theta cycles. Moreover, theta sequences reflected the rats’ decisions on the basis of their time estimation. These findings demonstrate that scalable features of time cells may support the capability of flexible temporal representation for memory formation. |
format | Online Article Text |
id | pubmed-7857679 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-78576792021-02-16 Scalable representation of time in the hippocampus Shimbo, Akihiro Izawa, Ei-Ichi Fujisawa, Shigeyoshi Sci Adv Research Articles Hippocampal “time cells” encode specific moments of temporally organized experiences that may support hippocampal functions for episodic memory. However, little is known about the reorganization of the temporal representation of time cells during changes in temporal structures of episodes. We investigated CA1 neuronal activity during temporal bisection tasks, in which the sets of time intervals to be discriminated were designed to be extended or contracted across the blocks of trials. Assemblies of neurons encoded elapsed time during the interval, and the representation was scaled when the set of interval times was varied. Theta phase precession and theta sequences of time cells were also scalable, and the fine temporal relationships were preserved between pairs in theta cycles. Moreover, theta sequences reflected the rats’ decisions on the basis of their time estimation. These findings demonstrate that scalable features of time cells may support the capability of flexible temporal representation for memory formation. American Association for the Advancement of Science 2021-02-03 /pmc/articles/PMC7857679/ /pubmed/33536211 http://dx.doi.org/10.1126/sciadv.abd7013 Text en Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/ https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Research Articles Shimbo, Akihiro Izawa, Ei-Ichi Fujisawa, Shigeyoshi Scalable representation of time in the hippocampus |
title | Scalable representation of time in the hippocampus |
title_full | Scalable representation of time in the hippocampus |
title_fullStr | Scalable representation of time in the hippocampus |
title_full_unstemmed | Scalable representation of time in the hippocampus |
title_short | Scalable representation of time in the hippocampus |
title_sort | scalable representation of time in the hippocampus |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857679/ https://www.ncbi.nlm.nih.gov/pubmed/33536211 http://dx.doi.org/10.1126/sciadv.abd7013 |
work_keys_str_mv | AT shimboakihiro scalablerepresentationoftimeinthehippocampus AT izawaeiichi scalablerepresentationoftimeinthehippocampus AT fujisawashigeyoshi scalablerepresentationoftimeinthehippocampus |