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Laminin γ2–mediating T cell exclusion attenuates response to anti–PD-1 therapy

PD-1/PD-L1 blockade therapies provide notable clinical benefits for patients with advanced cancers, but the factors influencing the effectiveness of the treatment remain incompletely cataloged. Here, the up-regulation of laminin γ2 (Ln-γ2) predicted the attenuated efficacy of anti–PD-1 drugs and was...

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Detalles Bibliográficos
Autores principales:	Li, Lei, Wei, Jia-Ru, Dong, Jun, Lin, Qing-Guang, Tang, Hong, Jia, Yong-Xu, Tan, Wanlin, Chen, Qing-Yun, Zeng, Ting-Ting, Xing, Shan, Qin, Yan-Ru, Zhu, Ying-Hui, Li, Yan, Guan, Xin-Yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857690/ https://www.ncbi.nlm.nih.gov/pubmed/33536206 http://dx.doi.org/10.1126/sciadv.abc8346

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