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Properdin oligomers adopt rigid extended conformations supporting function

Properdin stabilizes convertases formed upon activation of the complement cascade within the immune system. The biological activity of properdin depends on the oligomerization state, but whether properdin oligomers are rigid and how their structure links to function remains unknown. We show by combi...

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Detalles Bibliográficos
Autores principales:	Pedersen, Dennis V, Pedersen, Martin Nors, Mazarakis, Sofia MM, Wang, Yong, Lindorff-Larsen, Kresten, Arleth, Lise, Andersen, Gregers R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Immunology and Inflammation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857727/ https://www.ncbi.nlm.nih.gov/pubmed/33480354 http://dx.doi.org/10.7554/eLife.63356

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