Diverse viral proteases activate the NLRP1 inflammasome

The NLRP1 inflammasome is a multiprotein complex that is a potent activator of inflammation. Mouse NLRP1B can be activated through proteolytic cleavage by the bacterial Lethal Toxin (LeTx) protease, resulting in degradation of the N-terminal domains of NLRP1B and liberation of the bioactive C-termin...

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Detalles Bibliográficos
Autores principales: Tsu, Brian V, Beierschmitt, Christopher, Ryan, Andrew P, Agarwal, Rimjhim, Mitchell, Patrick S, Daugherty, Matthew D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857732/
https://www.ncbi.nlm.nih.gov/pubmed/33410748
http://dx.doi.org/10.7554/eLife.60609

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857732/
https://www.ncbi.nlm.nih.gov/pubmed/33410748
http://dx.doi.org/10.7554/eLife.60609

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