Calciprotein particles and fibroblast growth factor 23 contribute to the pathophysiology of hypercalcemia in a patient with renal sarcoidosis

In patients with sarcoidosis, dysregulated calcium metabolism is one of the frequently observed complications. However, little attention has been paid to abnormal phosphate metabolism. Herein we present the case of a 42-year-old Japanese man with renal sarcoidosis who developed acute kidney injury d...

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Autores principales: Iwazu, Yoshitaka, Kuro-o, Makoto, Miura, Yutaka, Takeda, Shin-ichi, Yamada, Toshiyuki, Nagata, Daisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Exceptional Cases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857787/
https://www.ncbi.nlm.nih.gov/pubmed/33564447
http://dx.doi.org/10.1093/ckj/sfz086
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author Iwazu, Yoshitaka
Kuro-o, Makoto
Miura, Yutaka
Takeda, Shin-ichi
Yamada, Toshiyuki
Nagata, Daisuke
author_facet Iwazu, Yoshitaka
Kuro-o, Makoto
Miura, Yutaka
Takeda, Shin-ichi
Yamada, Toshiyuki
Nagata, Daisuke
author_sort Iwazu, Yoshitaka
collection PubMed
description In patients with sarcoidosis, dysregulated calcium metabolism is one of the frequently observed complications. However, little attention has been paid to abnormal phosphate metabolism. Herein we present the case of a 42-year-old Japanese man with renal sarcoidosis who developed acute kidney injury due to hypercalcemia and nephrolithiasis. Laboratory data showed hypercalcemia with a normal serum phosphate level and high serum 1,25-hydroxyvitamin D(3), fibroblast growth factor 23 (FGF23) and calciprotein particle (CPP) levels. After treatment with oral prednisone and bisphosphonate, the laboratory abnormalities and renal dysfunction were resolved. Thus increases in FGF23 and CPP may indicate disturbed phosphate metabolism in renal sarcoidosis.
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spelling pubmed-78577872021-02-08 Calciprotein particles and fibroblast growth factor 23 contribute to the pathophysiology of hypercalcemia in a patient with renal sarcoidosis Iwazu, Yoshitaka Kuro-o, Makoto Miura, Yutaka Takeda, Shin-ichi Yamada, Toshiyuki Nagata, Daisuke Clin Kidney J Exceptional Cases In patients with sarcoidosis, dysregulated calcium metabolism is one of the frequently observed complications. However, little attention has been paid to abnormal phosphate metabolism. Herein we present the case of a 42-year-old Japanese man with renal sarcoidosis who developed acute kidney injury due to hypercalcemia and nephrolithiasis. Laboratory data showed hypercalcemia with a normal serum phosphate level and high serum 1,25-hydroxyvitamin D(3), fibroblast growth factor 23 (FGF23) and calciprotein particle (CPP) levels. After treatment with oral prednisone and bisphosphonate, the laboratory abnormalities and renal dysfunction were resolved. Thus increases in FGF23 and CPP may indicate disturbed phosphate metabolism in renal sarcoidosis. Oxford University Press 2019-08-04 /pmc/articles/PMC7857787/ /pubmed/33564447 http://dx.doi.org/10.1093/ckj/sfz086 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of ERA-EDTA. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Exceptional Cases
Iwazu, Yoshitaka
Kuro-o, Makoto
Miura, Yutaka
Takeda, Shin-ichi
Yamada, Toshiyuki
Nagata, Daisuke
Calciprotein particles and fibroblast growth factor 23 contribute to the pathophysiology of hypercalcemia in a patient with renal sarcoidosis
title Calciprotein particles and fibroblast growth factor 23 contribute to the pathophysiology of hypercalcemia in a patient with renal sarcoidosis
title_full Calciprotein particles and fibroblast growth factor 23 contribute to the pathophysiology of hypercalcemia in a patient with renal sarcoidosis
title_fullStr Calciprotein particles and fibroblast growth factor 23 contribute to the pathophysiology of hypercalcemia in a patient with renal sarcoidosis
title_full_unstemmed Calciprotein particles and fibroblast growth factor 23 contribute to the pathophysiology of hypercalcemia in a patient with renal sarcoidosis
title_short Calciprotein particles and fibroblast growth factor 23 contribute to the pathophysiology of hypercalcemia in a patient with renal sarcoidosis
title_sort calciprotein particles and fibroblast growth factor 23 contribute to the pathophysiology of hypercalcemia in a patient with renal sarcoidosis
topic Exceptional Cases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857787/
https://www.ncbi.nlm.nih.gov/pubmed/33564447
http://dx.doi.org/10.1093/ckj/sfz086
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