Podocyte and tubular involvement in AngioJet-induced kidney injury

The AngioJet technique combines localized thrombolysis and percutaneous mechanical thrombectomy (PMT). However, PMT may cause acute kidney injury (AKI), which has been ascribed to severe mechanical haemolysis, although no renal biopsies have been reported. We now report the first renal biopsy in a p...

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Detalles Bibliográficos
Autores principales: Esteras, Raquel, Cannata-Ortiz, Pablo, del Palacio-Tamarit, Marta, Guerrero-Hue, Melania, García-Caballero, Cristina, Egido, Jesús, Gimeno, Javier, Ortiz, Alberto, Gracia-Iguacel, Carolina, Moreno, Juan Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Exceptional Cases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857840/
https://www.ncbi.nlm.nih.gov/pubmed/33564448
http://dx.doi.org/10.1093/ckj/sfz104
Descripción
Sumario:The AngioJet technique combines localized thrombolysis and percutaneous mechanical thrombectomy (PMT). However, PMT may cause acute kidney injury (AKI), which has been ascribed to severe mechanical haemolysis, although no renal biopsies have been reported. We now report the first renal biopsy in a patient with AKI following PMT. There is histological evidence of haemoglobin (Hb)-induced tubular injury and podocyte stress characterized by intracellular Hb and staining for ferritin and hemo-oxygenase-1, suggestive of an adaptive response to oxidative stress. This confirms that Hb is involved in kidney cell injury and supports the existence of several different kidney cellular targets.

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