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The role of oxidative stress in the development of obesity and obesity-related metabolic disorders
Obesity is a serious medical condition, defined as excessive accumulation of fat. Abdominal fat is recognized as the major risk for obesity related diseases such as: hypertension, dyslipidemia, type 2 diabetes mellitus, coronary heart disease, stroke, non-alcoholic fatty liver disease etc. Fat accum...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society of Medical Biochemists of Serbia, Belgrade
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857849/ https://www.ncbi.nlm.nih.gov/pubmed/33584134 http://dx.doi.org/10.5937/jomb0-24652 |
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author | Čolak, Emina Pap, Dragana |
author_facet | Čolak, Emina Pap, Dragana |
author_sort | Čolak, Emina |
collection | PubMed |
description | Obesity is a serious medical condition, defined as excessive accumulation of fat. Abdominal fat is recognized as the major risk for obesity related diseases such as: hypertension, dyslipidemia, type 2 diabetes mellitus, coronary heart disease, stroke, non-alcoholic fatty liver disease etc. Fat accumulation is also related to pro-oxidant and pro-inflammatory states. Recently published articles suggest that oxidative stress may be a link between obesity and related complications. Adiposity leads to increased oxidative stress via several multiple biochemical processes such as superoxide generation through the action of NADPH oxidase, glyceraldehyde auto-oxidation, oxidative phosphorylation, protein kinase C (PKC) activation, and polyol and hexosamine pathways. On the other hand, oxidative stress plays a causative role in the development of obesity, by stimulating the deposition of adipose tissue, including preadipocyte proliferation, adipocyte differentiation and growth. Exercise-induced weight loss can improve the redox state by modulating both oxidative stress and antioxidant promoters, which reduce endothelial dysfunction and inflammation. |
format | Online Article Text |
id | pubmed-7857849 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Society of Medical Biochemists of Serbia, Belgrade |
record_format | MEDLINE/PubMed |
spelling | pubmed-78578492021-02-12 The role of oxidative stress in the development of obesity and obesity-related metabolic disorders Čolak, Emina Pap, Dragana J Med Biochem Review Paper Obesity is a serious medical condition, defined as excessive accumulation of fat. Abdominal fat is recognized as the major risk for obesity related diseases such as: hypertension, dyslipidemia, type 2 diabetes mellitus, coronary heart disease, stroke, non-alcoholic fatty liver disease etc. Fat accumulation is also related to pro-oxidant and pro-inflammatory states. Recently published articles suggest that oxidative stress may be a link between obesity and related complications. Adiposity leads to increased oxidative stress via several multiple biochemical processes such as superoxide generation through the action of NADPH oxidase, glyceraldehyde auto-oxidation, oxidative phosphorylation, protein kinase C (PKC) activation, and polyol and hexosamine pathways. On the other hand, oxidative stress plays a causative role in the development of obesity, by stimulating the deposition of adipose tissue, including preadipocyte proliferation, adipocyte differentiation and growth. Exercise-induced weight loss can improve the redox state by modulating both oxidative stress and antioxidant promoters, which reduce endothelial dysfunction and inflammation. Society of Medical Biochemists of Serbia, Belgrade 2021-01-26 2021-01-26 /pmc/articles/PMC7857849/ /pubmed/33584134 http://dx.doi.org/10.5937/jomb0-24652 Text en 2021 Emina Čolak, Dragana Pap, published by CEON/CEES http://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 License. |
spellingShingle | Review Paper Čolak, Emina Pap, Dragana The role of oxidative stress in the development of obesity and obesity-related metabolic disorders |
title | The role of oxidative stress in the development of obesity and obesity-related metabolic disorders |
title_full | The role of oxidative stress in the development of obesity and obesity-related metabolic disorders |
title_fullStr | The role of oxidative stress in the development of obesity and obesity-related metabolic disorders |
title_full_unstemmed | The role of oxidative stress in the development of obesity and obesity-related metabolic disorders |
title_short | The role of oxidative stress in the development of obesity and obesity-related metabolic disorders |
title_sort | role of oxidative stress in the development of obesity and obesity-related metabolic disorders |
topic | Review Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857849/ https://www.ncbi.nlm.nih.gov/pubmed/33584134 http://dx.doi.org/10.5937/jomb0-24652 |
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