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Ethnopharmacology, Phytochemistry, and Pharmacological Properties of Thymus satureioides Coss.
Thymus satureioides Coss. (Lamiaceae) is a Moroccan medicinal plant locally known as “Azkouni” or “Zaitra.” It is widely used in traditional medicine to treat various ailments, including hypertension, diabetes, cold, fever, dermatological and circulatory disorders, immune problems, bronchitis, nocic...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857882/ https://www.ncbi.nlm.nih.gov/pubmed/33574883 http://dx.doi.org/10.1155/2021/6673838 |
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author | El Hachlafi, Naoufal Chebat, Abderrahim Fikri-Benbrahim, Kawtar |
author_facet | El Hachlafi, Naoufal Chebat, Abderrahim Fikri-Benbrahim, Kawtar |
author_sort | El Hachlafi, Naoufal |
collection | PubMed |
description | Thymus satureioides Coss. (Lamiaceae) is a Moroccan medicinal plant locally known as “Azkouni” or “Zaitra.” It is widely used in traditional medicine to treat various ailments, including hypertension, diabetes, cold, fever, dermatological and circulatory disorders, immune problems, bronchitis, nociception, cooling, pharyngitis, cough, and influenza. The current review aims to critically summarize the literature on ethnopharmacological uses, chemical profile, and pharmacological investigations of T. satureioides in order to provide data support and scientific evidences for further investigations. Electronic databases such as Scopus, PubMed, Web of Science, SciFinder, ScienceDirect, Google Scholar, and Medline were used to gather data on T. satureioides. Chemical characterization of T. satureioides essential oils (EOs) and extracts allowed to identify a total of 139 bioactive compounds, mainly belonging to the terpenoids, phenolic acids, and flavonoids classes. T. satureioides especially its essential oils exhibited numerous biological activities such as antibacterial, antifungal, anti-inflammatory, antioxidant, antidiabetic, anticancer, antiparasitic, and hypolipedemic activities. In light of these findings, further studies to transmute the traditional application of T. satureioides into scientific-based information are strongly required. Additional in vivo pharmacological studies are recommended to validate the results of the in vitro studies. Moreover, comprehensive preclinical and clinical trials on the pharmacological mechanisms of action of this plant and its bioactive compounds on molecular targets should be performed. Finally, more efforts must be focused on toxicological assessments and pharmacokinetic studies, in order to ensure the safety and the efficiency of T. satureioides. |
format | Online Article Text |
id | pubmed-7857882 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-78578822021-02-10 Ethnopharmacology, Phytochemistry, and Pharmacological Properties of Thymus satureioides Coss. El Hachlafi, Naoufal Chebat, Abderrahim Fikri-Benbrahim, Kawtar Evid Based Complement Alternat Med Review Article Thymus satureioides Coss. (Lamiaceae) is a Moroccan medicinal plant locally known as “Azkouni” or “Zaitra.” It is widely used in traditional medicine to treat various ailments, including hypertension, diabetes, cold, fever, dermatological and circulatory disorders, immune problems, bronchitis, nociception, cooling, pharyngitis, cough, and influenza. The current review aims to critically summarize the literature on ethnopharmacological uses, chemical profile, and pharmacological investigations of T. satureioides in order to provide data support and scientific evidences for further investigations. Electronic databases such as Scopus, PubMed, Web of Science, SciFinder, ScienceDirect, Google Scholar, and Medline were used to gather data on T. satureioides. Chemical characterization of T. satureioides essential oils (EOs) and extracts allowed to identify a total of 139 bioactive compounds, mainly belonging to the terpenoids, phenolic acids, and flavonoids classes. T. satureioides especially its essential oils exhibited numerous biological activities such as antibacterial, antifungal, anti-inflammatory, antioxidant, antidiabetic, anticancer, antiparasitic, and hypolipedemic activities. In light of these findings, further studies to transmute the traditional application of T. satureioides into scientific-based information are strongly required. Additional in vivo pharmacological studies are recommended to validate the results of the in vitro studies. Moreover, comprehensive preclinical and clinical trials on the pharmacological mechanisms of action of this plant and its bioactive compounds on molecular targets should be performed. Finally, more efforts must be focused on toxicological assessments and pharmacokinetic studies, in order to ensure the safety and the efficiency of T. satureioides. Hindawi 2021-01-27 /pmc/articles/PMC7857882/ /pubmed/33574883 http://dx.doi.org/10.1155/2021/6673838 Text en Copyright © 2021 Naoufal El Hachlafi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article El Hachlafi, Naoufal Chebat, Abderrahim Fikri-Benbrahim, Kawtar Ethnopharmacology, Phytochemistry, and Pharmacological Properties of Thymus satureioides Coss. |
title | Ethnopharmacology, Phytochemistry, and Pharmacological Properties of Thymus satureioides Coss. |
title_full | Ethnopharmacology, Phytochemistry, and Pharmacological Properties of Thymus satureioides Coss. |
title_fullStr | Ethnopharmacology, Phytochemistry, and Pharmacological Properties of Thymus satureioides Coss. |
title_full_unstemmed | Ethnopharmacology, Phytochemistry, and Pharmacological Properties of Thymus satureioides Coss. |
title_short | Ethnopharmacology, Phytochemistry, and Pharmacological Properties of Thymus satureioides Coss. |
title_sort | ethnopharmacology, phytochemistry, and pharmacological properties of thymus satureioides coss. |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857882/ https://www.ncbi.nlm.nih.gov/pubmed/33574883 http://dx.doi.org/10.1155/2021/6673838 |
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