Cargando…

Ethnopharmacology, Phytochemistry, and Pharmacological Properties of Thymus satureioides Coss.

Thymus satureioides Coss. (Lamiaceae) is a Moroccan medicinal plant locally known as “Azkouni” or “Zaitra.” It is widely used in traditional medicine to treat various ailments, including hypertension, diabetes, cold, fever, dermatological and circulatory disorders, immune problems, bronchitis, nocic...

Descripción completa

Detalles Bibliográficos
Autores principales: El Hachlafi, Naoufal, Chebat, Abderrahim, Fikri-Benbrahim, Kawtar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857882/
https://www.ncbi.nlm.nih.gov/pubmed/33574883
http://dx.doi.org/10.1155/2021/6673838
_version_ 1783646533152931840
author El Hachlafi, Naoufal
Chebat, Abderrahim
Fikri-Benbrahim, Kawtar
author_facet El Hachlafi, Naoufal
Chebat, Abderrahim
Fikri-Benbrahim, Kawtar
author_sort El Hachlafi, Naoufal
collection PubMed
description Thymus satureioides Coss. (Lamiaceae) is a Moroccan medicinal plant locally known as “Azkouni” or “Zaitra.” It is widely used in traditional medicine to treat various ailments, including hypertension, diabetes, cold, fever, dermatological and circulatory disorders, immune problems, bronchitis, nociception, cooling, pharyngitis, cough, and influenza. The current review aims to critically summarize the literature on ethnopharmacological uses, chemical profile, and pharmacological investigations of T. satureioides in order to provide data support and scientific evidences for further investigations. Electronic databases such as Scopus, PubMed, Web of Science, SciFinder, ScienceDirect, Google Scholar, and Medline were used to gather data on T. satureioides. Chemical characterization of T. satureioides essential oils (EOs) and extracts allowed to identify a total of 139 bioactive compounds, mainly belonging to the terpenoids, phenolic acids, and flavonoids classes. T. satureioides especially its essential oils exhibited numerous biological activities such as antibacterial, antifungal, anti-inflammatory, antioxidant, antidiabetic, anticancer, antiparasitic, and hypolipedemic activities. In light of these findings, further studies to transmute the traditional application of T. satureioides into scientific-based information are strongly required. Additional in vivo pharmacological studies are recommended to validate the results of the in vitro studies. Moreover, comprehensive preclinical and clinical trials on the pharmacological mechanisms of action of this plant and its bioactive compounds on molecular targets should be performed. Finally, more efforts must be focused on toxicological assessments and pharmacokinetic studies, in order to ensure the safety and the efficiency of T. satureioides.
format Online
Article
Text
id pubmed-7857882
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-78578822021-02-10 Ethnopharmacology, Phytochemistry, and Pharmacological Properties of Thymus satureioides Coss. El Hachlafi, Naoufal Chebat, Abderrahim Fikri-Benbrahim, Kawtar Evid Based Complement Alternat Med Review Article Thymus satureioides Coss. (Lamiaceae) is a Moroccan medicinal plant locally known as “Azkouni” or “Zaitra.” It is widely used in traditional medicine to treat various ailments, including hypertension, diabetes, cold, fever, dermatological and circulatory disorders, immune problems, bronchitis, nociception, cooling, pharyngitis, cough, and influenza. The current review aims to critically summarize the literature on ethnopharmacological uses, chemical profile, and pharmacological investigations of T. satureioides in order to provide data support and scientific evidences for further investigations. Electronic databases such as Scopus, PubMed, Web of Science, SciFinder, ScienceDirect, Google Scholar, and Medline were used to gather data on T. satureioides. Chemical characterization of T. satureioides essential oils (EOs) and extracts allowed to identify a total of 139 bioactive compounds, mainly belonging to the terpenoids, phenolic acids, and flavonoids classes. T. satureioides especially its essential oils exhibited numerous biological activities such as antibacterial, antifungal, anti-inflammatory, antioxidant, antidiabetic, anticancer, antiparasitic, and hypolipedemic activities. In light of these findings, further studies to transmute the traditional application of T. satureioides into scientific-based information are strongly required. Additional in vivo pharmacological studies are recommended to validate the results of the in vitro studies. Moreover, comprehensive preclinical and clinical trials on the pharmacological mechanisms of action of this plant and its bioactive compounds on molecular targets should be performed. Finally, more efforts must be focused on toxicological assessments and pharmacokinetic studies, in order to ensure the safety and the efficiency of T. satureioides. Hindawi 2021-01-27 /pmc/articles/PMC7857882/ /pubmed/33574883 http://dx.doi.org/10.1155/2021/6673838 Text en Copyright © 2021 Naoufal El Hachlafi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
El Hachlafi, Naoufal
Chebat, Abderrahim
Fikri-Benbrahim, Kawtar
Ethnopharmacology, Phytochemistry, and Pharmacological Properties of Thymus satureioides Coss.
title Ethnopharmacology, Phytochemistry, and Pharmacological Properties of Thymus satureioides Coss.
title_full Ethnopharmacology, Phytochemistry, and Pharmacological Properties of Thymus satureioides Coss.
title_fullStr Ethnopharmacology, Phytochemistry, and Pharmacological Properties of Thymus satureioides Coss.
title_full_unstemmed Ethnopharmacology, Phytochemistry, and Pharmacological Properties of Thymus satureioides Coss.
title_short Ethnopharmacology, Phytochemistry, and Pharmacological Properties of Thymus satureioides Coss.
title_sort ethnopharmacology, phytochemistry, and pharmacological properties of thymus satureioides coss.
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857882/
https://www.ncbi.nlm.nih.gov/pubmed/33574883
http://dx.doi.org/10.1155/2021/6673838
work_keys_str_mv AT elhachlafinaoufal ethnopharmacologyphytochemistryandpharmacologicalpropertiesofthymussatureioidescoss
AT chebatabderrahim ethnopharmacologyphytochemistryandpharmacologicalpropertiesofthymussatureioidescoss
AT fikribenbrahimkawtar ethnopharmacologyphytochemistryandpharmacologicalpropertiesofthymussatureioidescoss