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Role of Oxidative Stress in the Mechanisms of Anthracycline-Induced Cardiotoxicity: Effects of Preventive Strategies

Anthracycline-induced cardiotoxicity (AIC) persists as a significant cause of morbidity and mortality in cancer survivors. Although many protective strategies have been evaluated, cardiotoxicity remains an ongoing threat. The mechanisms of AIC remain unclear; however, several pathways have been prop...

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Autores principales: Carrasco, Rodrigo, Castillo, Rodrigo L., Gormaz, Juan G., Carrillo, Montserrat, Thavendiranathan, Paaladinesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857913/
https://www.ncbi.nlm.nih.gov/pubmed/33574985
http://dx.doi.org/10.1155/2021/8863789
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author Carrasco, Rodrigo
Castillo, Rodrigo L.
Gormaz, Juan G.
Carrillo, Montserrat
Thavendiranathan, Paaladinesh
author_facet Carrasco, Rodrigo
Castillo, Rodrigo L.
Gormaz, Juan G.
Carrillo, Montserrat
Thavendiranathan, Paaladinesh
author_sort Carrasco, Rodrigo
collection PubMed
description Anthracycline-induced cardiotoxicity (AIC) persists as a significant cause of morbidity and mortality in cancer survivors. Although many protective strategies have been evaluated, cardiotoxicity remains an ongoing threat. The mechanisms of AIC remain unclear; however, several pathways have been proposed, suggesting a multifactorial origin. When the central role of topoisomerase 2β in the pathophysiology of AIC was described some years ago, the classical reactive oxygen species (ROS) hypothesis shifted to a secondary position. However, new insights have reemphasized the importance of the role of oxidative stress-mediated signaling as a common pathway and a critical modulator of the different mechanisms involved in AIC. A better understanding of the mechanisms of cardiotoxicity is crucial for the development of treatment strategies. It has been suggested that the available therapeutic interventions for AIC could act on the modulation of oxidative balance, leading to a reduction in oxidative stress injury. These indirect antioxidant effects make them an option for the primary prevention of AIC. In this review, our objective is to provide an update of the accumulated knowledge on the role of oxidative stress in AIC and the modulation of the redox balance by potential preventive strategies.
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spelling pubmed-78579132021-02-10 Role of Oxidative Stress in the Mechanisms of Anthracycline-Induced Cardiotoxicity: Effects of Preventive Strategies Carrasco, Rodrigo Castillo, Rodrigo L. Gormaz, Juan G. Carrillo, Montserrat Thavendiranathan, Paaladinesh Oxid Med Cell Longev Review Article Anthracycline-induced cardiotoxicity (AIC) persists as a significant cause of morbidity and mortality in cancer survivors. Although many protective strategies have been evaluated, cardiotoxicity remains an ongoing threat. The mechanisms of AIC remain unclear; however, several pathways have been proposed, suggesting a multifactorial origin. When the central role of topoisomerase 2β in the pathophysiology of AIC was described some years ago, the classical reactive oxygen species (ROS) hypothesis shifted to a secondary position. However, new insights have reemphasized the importance of the role of oxidative stress-mediated signaling as a common pathway and a critical modulator of the different mechanisms involved in AIC. A better understanding of the mechanisms of cardiotoxicity is crucial for the development of treatment strategies. It has been suggested that the available therapeutic interventions for AIC could act on the modulation of oxidative balance, leading to a reduction in oxidative stress injury. These indirect antioxidant effects make them an option for the primary prevention of AIC. In this review, our objective is to provide an update of the accumulated knowledge on the role of oxidative stress in AIC and the modulation of the redox balance by potential preventive strategies. Hindawi 2021-01-25 /pmc/articles/PMC7857913/ /pubmed/33574985 http://dx.doi.org/10.1155/2021/8863789 Text en Copyright © 2021 Rodrigo Carrasco et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Carrasco, Rodrigo
Castillo, Rodrigo L.
Gormaz, Juan G.
Carrillo, Montserrat
Thavendiranathan, Paaladinesh
Role of Oxidative Stress in the Mechanisms of Anthracycline-Induced Cardiotoxicity: Effects of Preventive Strategies
title Role of Oxidative Stress in the Mechanisms of Anthracycline-Induced Cardiotoxicity: Effects of Preventive Strategies
title_full Role of Oxidative Stress in the Mechanisms of Anthracycline-Induced Cardiotoxicity: Effects of Preventive Strategies
title_fullStr Role of Oxidative Stress in the Mechanisms of Anthracycline-Induced Cardiotoxicity: Effects of Preventive Strategies
title_full_unstemmed Role of Oxidative Stress in the Mechanisms of Anthracycline-Induced Cardiotoxicity: Effects of Preventive Strategies
title_short Role of Oxidative Stress in the Mechanisms of Anthracycline-Induced Cardiotoxicity: Effects of Preventive Strategies
title_sort role of oxidative stress in the mechanisms of anthracycline-induced cardiotoxicity: effects of preventive strategies
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857913/
https://www.ncbi.nlm.nih.gov/pubmed/33574985
http://dx.doi.org/10.1155/2021/8863789
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