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The three frontlines against COVID-19: Brain, Behavior, and Immunity
The pandemic outbreak of coronavirus disease 2019 (COVID-19) is raising global anxiety and fear of both real and perceived health threat from the virus. Overwhelming evidence shows infected patients experiencing neuropsychiatric complications, suggesting that the “psychoneuroimmunity” model might be...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857976/ https://www.ncbi.nlm.nih.gov/pubmed/33548496 http://dx.doi.org/10.1016/j.bbi.2021.01.030 |
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author | Wang, Shao-Cheng Su, Kuan-Pin Pariante, Carmine M. |
author_facet | Wang, Shao-Cheng Su, Kuan-Pin Pariante, Carmine M. |
author_sort | Wang, Shao-Cheng |
collection | PubMed |
description | The pandemic outbreak of coronavirus disease 2019 (COVID-19) is raising global anxiety and fear of both real and perceived health threat from the virus. Overwhelming evidence shows infected patients experiencing neuropsychiatric complications, suggesting that the “psychoneuroimmunity” model might be beneficial in understanding the impact of the virus. Therefore, this Special Issue on “Immunopsychiatry of COVID-19 Pandemic” was launched immediately after the pandemic was declared, with the first paper accepted on the March 25th, 2020. A total of ninety-three papers were accepted, the last one was on the July 10th, 2020 when the initial acute phase started declining. The papers of this Special Issue have illuminated the social impact, psychopathology, neurological manifestation, immunity responses, and potential treatments and prevention on COVID-19. For example, anxiety disorders, mood disorders, and suicidal ideation are most common psychiatric manifestations. COVID-19 infection can have central and/or peripheral nervous system symptoms, including headache, sleep disorders, encephalopathy, and loss of taste and smell. A “three-steps” Neuro-COVID infection model (neuro-invasion, clearance and immune response) was established. The current therapeutic interventions for COVID-19 include supportive intervention, immunomodulatory agents, antiviral therapy, and plasma transfusion. Psychological support should be implemented, improving the psychological wellbeing, as well as to enhance psychoneuroimmunity against COVID-19. |
format | Online Article Text |
id | pubmed-7857976 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78579762021-02-04 The three frontlines against COVID-19: Brain, Behavior, and Immunity Wang, Shao-Cheng Su, Kuan-Pin Pariante, Carmine M. Brain Behav Immun Viewpoint The pandemic outbreak of coronavirus disease 2019 (COVID-19) is raising global anxiety and fear of both real and perceived health threat from the virus. Overwhelming evidence shows infected patients experiencing neuropsychiatric complications, suggesting that the “psychoneuroimmunity” model might be beneficial in understanding the impact of the virus. Therefore, this Special Issue on “Immunopsychiatry of COVID-19 Pandemic” was launched immediately after the pandemic was declared, with the first paper accepted on the March 25th, 2020. A total of ninety-three papers were accepted, the last one was on the July 10th, 2020 when the initial acute phase started declining. The papers of this Special Issue have illuminated the social impact, psychopathology, neurological manifestation, immunity responses, and potential treatments and prevention on COVID-19. For example, anxiety disorders, mood disorders, and suicidal ideation are most common psychiatric manifestations. COVID-19 infection can have central and/or peripheral nervous system symptoms, including headache, sleep disorders, encephalopathy, and loss of taste and smell. A “three-steps” Neuro-COVID infection model (neuro-invasion, clearance and immune response) was established. The current therapeutic interventions for COVID-19 include supportive intervention, immunomodulatory agents, antiviral therapy, and plasma transfusion. Psychological support should be implemented, improving the psychological wellbeing, as well as to enhance psychoneuroimmunity against COVID-19. Elsevier Inc. 2021-03 2021-02-04 /pmc/articles/PMC7857976/ /pubmed/33548496 http://dx.doi.org/10.1016/j.bbi.2021.01.030 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Viewpoint Wang, Shao-Cheng Su, Kuan-Pin Pariante, Carmine M. The three frontlines against COVID-19: Brain, Behavior, and Immunity |
title | The three frontlines against COVID-19: Brain, Behavior, and Immunity |
title_full | The three frontlines against COVID-19: Brain, Behavior, and Immunity |
title_fullStr | The three frontlines against COVID-19: Brain, Behavior, and Immunity |
title_full_unstemmed | The three frontlines against COVID-19: Brain, Behavior, and Immunity |
title_short | The three frontlines against COVID-19: Brain, Behavior, and Immunity |
title_sort | three frontlines against covid-19: brain, behavior, and immunity |
topic | Viewpoint |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857976/ https://www.ncbi.nlm.nih.gov/pubmed/33548496 http://dx.doi.org/10.1016/j.bbi.2021.01.030 |
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