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Primary bone sarcomas in KSA: A Saudi tumor registry review

OBJECTIVES: The geographical incidence of tumours is usually influenced by the environment, race, and culture. This study aimed to report the incidence and differences in tumour type, site of origin, and mortality across gender, regions, age, and the different characteristics of tumour types. METHOD...

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Detalles Bibliográficos
Autores principales: Aljuhani, Wazzan S., Alanazi, Abdullah M., Alghafees, Mohammad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taibah University 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7858035/
https://www.ncbi.nlm.nih.gov/pubmed/33603635
http://dx.doi.org/10.1016/j.jtumed.2020.11.001
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author Aljuhani, Wazzan S.
Alanazi, Abdullah M.
Alghafees, Mohammad A.
author_facet Aljuhani, Wazzan S.
Alanazi, Abdullah M.
Alghafees, Mohammad A.
author_sort Aljuhani, Wazzan S.
collection PubMed
description OBJECTIVES: The geographical incidence of tumours is usually influenced by the environment, race, and culture. This study aimed to report the incidence and differences in tumour type, site of origin, and mortality across gender, regions, age, and the different characteristics of tumour types. METHODS: This retrospective cohort study included all patients diagnosed with primary bone sarcomas from January 1, 2013, to December 31, 2017. Frequencies and percentages were generated for categorical variables. Means and standard deviations were calculated for quantitative variables. A chi-squared test was used to detect differences among categorical variables. Student-t, ANOVA, and Tukey tests were used to detect differences among quantitative variables. Lastly, we calculated the incidence of each tumour type. RESULTS: Of 451 patients, 248 (55%) had osteosarcomas; 160 (35.5%) had Ewing's sarcoma, and 43 (9.5%) had chondrosarcoma. The incidence was 1.56 cases per 1,000,000 per year for osteosarcoma, 0.95 cases per 1,000,000 per year for Ewing's sarcoma, and 0.27 cases per million per year for chondrosarcoma. The three-year survival rate was 82.30%. Significant differences in tumour type, origin site, and three-year survival across age and gender were detected. Similarly, significant differences were also noted in origin site, grade, basis of diagnosis, and lateralisation across tumour types. CONCLUSIONS: In our study, the observed bone sarcoma incidence rates were lower than the ones reported worldwide. Understanding the pattern of tumour behaviour in the region will help develop a risk and response-based treatment plan for early decision-making.
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spelling pubmed-78580352021-02-17 Primary bone sarcomas in KSA: A Saudi tumor registry review Aljuhani, Wazzan S. Alanazi, Abdullah M. Alghafees, Mohammad A. J Taibah Univ Med Sci Original Article OBJECTIVES: The geographical incidence of tumours is usually influenced by the environment, race, and culture. This study aimed to report the incidence and differences in tumour type, site of origin, and mortality across gender, regions, age, and the different characteristics of tumour types. METHODS: This retrospective cohort study included all patients diagnosed with primary bone sarcomas from January 1, 2013, to December 31, 2017. Frequencies and percentages were generated for categorical variables. Means and standard deviations were calculated for quantitative variables. A chi-squared test was used to detect differences among categorical variables. Student-t, ANOVA, and Tukey tests were used to detect differences among quantitative variables. Lastly, we calculated the incidence of each tumour type. RESULTS: Of 451 patients, 248 (55%) had osteosarcomas; 160 (35.5%) had Ewing's sarcoma, and 43 (9.5%) had chondrosarcoma. The incidence was 1.56 cases per 1,000,000 per year for osteosarcoma, 0.95 cases per 1,000,000 per year for Ewing's sarcoma, and 0.27 cases per million per year for chondrosarcoma. The three-year survival rate was 82.30%. Significant differences in tumour type, origin site, and three-year survival across age and gender were detected. Similarly, significant differences were also noted in origin site, grade, basis of diagnosis, and lateralisation across tumour types. CONCLUSIONS: In our study, the observed bone sarcoma incidence rates were lower than the ones reported worldwide. Understanding the pattern of tumour behaviour in the region will help develop a risk and response-based treatment plan for early decision-making. Taibah University 2020-12-01 /pmc/articles/PMC7858035/ /pubmed/33603635 http://dx.doi.org/10.1016/j.jtumed.2020.11.001 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Aljuhani, Wazzan S.
Alanazi, Abdullah M.
Alghafees, Mohammad A.
Primary bone sarcomas in KSA: A Saudi tumor registry review
title Primary bone sarcomas in KSA: A Saudi tumor registry review
title_full Primary bone sarcomas in KSA: A Saudi tumor registry review
title_fullStr Primary bone sarcomas in KSA: A Saudi tumor registry review
title_full_unstemmed Primary bone sarcomas in KSA: A Saudi tumor registry review
title_short Primary bone sarcomas in KSA: A Saudi tumor registry review
title_sort primary bone sarcomas in ksa: a saudi tumor registry review
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7858035/
https://www.ncbi.nlm.nih.gov/pubmed/33603635
http://dx.doi.org/10.1016/j.jtumed.2020.11.001
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