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Plasmodium falciparum Guanylyl Cyclase-Alpha and the Activity of Its Appended P4-ATPase Domain Are Essential for cGMP Synthesis and Blood-Stage Egress

Guanylyl cyclases (GCs) synthesize cyclic GMP (cGMP) and, together with cyclic nucleotide phosphodiesterases, are responsible for regulating levels of this intracellular messenger which mediates myriad functions across eukaryotes. In malaria parasites (Plasmodium spp), as well as their apicomplexan...

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Detalles Bibliográficos
Autores principales:	Nofal, Stephanie D., Patel, Avnish, Blackman, Michael J., Flueck, Christian, Baker, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7858053/ https://www.ncbi.nlm.nih.gov/pubmed/33500341 http://dx.doi.org/10.1128/mBio.02694-20

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