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Sirtuin 3 Downregulation in Mycobacterium tuberculosis-Infected Macrophages Reprograms Mitochondrial Metabolism and Promotes Cell Death

Mycobacterium tuberculosis induces metabolic reprogramming in macrophages like the Warburg effect. This enhances antimicrobial performance at the expense of increased inflammation, which may promote a pathogen-permissive host environment. Since the NAD(+)-dependent protein deacetylase Sirtuin 3 (SIR...

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Detalles Bibliográficos
Autores principales:	Smulan, Lorissa J., Martinez, Nuria, Kiritsy, Michael C., Kativhu, Chido, Cavallo, Kelly, Sassetti, Christopher M., Singhal, Amit, Remold, Heinz G., Kornfeld, Hardy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7858060/ https://www.ncbi.nlm.nih.gov/pubmed/33531400 http://dx.doi.org/10.1128/mBio.03140-20

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