(p)ppGpp/GTP and Malonyl-CoA Modulate Staphylococcus aureus Adaptation to FASII Antibiotics and Provide a Basis for Synergistic Bi-Therapy

Fatty acid biosynthesis (FASII) enzymes are considered valid targets for antimicrobial drug development against the human pathogen Staphylococcus aureus. However, incorporation of host fatty acids confers FASII antibiotic adaptation that compromises prospective treatments. S. aureus adapts to FASII...

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Detalles Bibliográficos
Autores principales: Pathania, Amit, Anba-Mondoloni, Jamila, Gominet, Myriam, Halpern, David, Dairou, Julien, Dupont, Laëtitia, Lamberet, Gilles, Trieu-Cuot, Patrick, Gloux, Karine, Gruss, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7858065/
https://www.ncbi.nlm.nih.gov/pubmed/33531402
http://dx.doi.org/10.1128/mBio.03193-20

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