Antiproliferative Sorbicillinoids From the Deep-Sea-Derived Penicillium allii-sativi

Two new (1–2) and three known (3–5) sorbicillinoids were isolated from the deep-sea-derived fungus Penicillium allii-sativi MCCC 3A00580. Compounds 1 and 2, named sorbicatechols C and D, were two new hybrid dihydrosorbillinoids. Their structures were established mainly by spectroscopic analyses and...

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Autores principales: Xie, Chun-Lan, Zhang, Duo, Lin, Ting, He, Zhi-Hui, Yan, Qing-Xiang, Cai, Qi, Zhang, Xiao-Kun, Yang, Xian-Wen, Chen, Hai-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7858254/
https://www.ncbi.nlm.nih.gov/pubmed/33552036
http://dx.doi.org/10.3389/fmicb.2020.636948
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author Xie, Chun-Lan
Zhang, Duo
Lin, Ting
He, Zhi-Hui
Yan, Qing-Xiang
Cai, Qi
Zhang, Xiao-Kun
Yang, Xian-Wen
Chen, Hai-Feng
author_facet Xie, Chun-Lan
Zhang, Duo
Lin, Ting
He, Zhi-Hui
Yan, Qing-Xiang
Cai, Qi
Zhang, Xiao-Kun
Yang, Xian-Wen
Chen, Hai-Feng
author_sort Xie, Chun-Lan
collection PubMed
description Two new (1–2) and three known (3–5) sorbicillinoids were isolated from the deep-sea-derived fungus Penicillium allii-sativi MCCC 3A00580. Compounds 1 and 2, named sorbicatechols C and D, were two new hybrid dihydrosorbillinoids. Their structures were established mainly by spectroscopic analyses and electronic circular dichroism (ECD) calculations. All five isolates were tested for antiproliferative activities against four tumor cell lines of MCF-7, HT-29, HuH-7, and LNCap. Compounds 2 and 5 inhibited HT-29 cells in a good dose-dependent manner. Mechanism investigation uncovered that they could significantly induce cell cycle G2-M phase arresting by increasing the protein levels of p-H3 and cyclin B1.
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spelling pubmed-78582542021-02-05 Antiproliferative Sorbicillinoids From the Deep-Sea-Derived Penicillium allii-sativi Xie, Chun-Lan Zhang, Duo Lin, Ting He, Zhi-Hui Yan, Qing-Xiang Cai, Qi Zhang, Xiao-Kun Yang, Xian-Wen Chen, Hai-Feng Front Microbiol Microbiology Two new (1–2) and three known (3–5) sorbicillinoids were isolated from the deep-sea-derived fungus Penicillium allii-sativi MCCC 3A00580. Compounds 1 and 2, named sorbicatechols C and D, were two new hybrid dihydrosorbillinoids. Their structures were established mainly by spectroscopic analyses and electronic circular dichroism (ECD) calculations. All five isolates were tested for antiproliferative activities against four tumor cell lines of MCF-7, HT-29, HuH-7, and LNCap. Compounds 2 and 5 inhibited HT-29 cells in a good dose-dependent manner. Mechanism investigation uncovered that they could significantly induce cell cycle G2-M phase arresting by increasing the protein levels of p-H3 and cyclin B1. Frontiers Media S.A. 2021-01-21 /pmc/articles/PMC7858254/ /pubmed/33552036 http://dx.doi.org/10.3389/fmicb.2020.636948 Text en Copyright © 2021 Xie, Zhang, Lin, He, Yan, Cai, Zhang, Yang and Chen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Xie, Chun-Lan
Zhang, Duo
Lin, Ting
He, Zhi-Hui
Yan, Qing-Xiang
Cai, Qi
Zhang, Xiao-Kun
Yang, Xian-Wen
Chen, Hai-Feng
Antiproliferative Sorbicillinoids From the Deep-Sea-Derived Penicillium allii-sativi
title Antiproliferative Sorbicillinoids From the Deep-Sea-Derived Penicillium allii-sativi
title_full Antiproliferative Sorbicillinoids From the Deep-Sea-Derived Penicillium allii-sativi
title_fullStr Antiproliferative Sorbicillinoids From the Deep-Sea-Derived Penicillium allii-sativi
title_full_unstemmed Antiproliferative Sorbicillinoids From the Deep-Sea-Derived Penicillium allii-sativi
title_short Antiproliferative Sorbicillinoids From the Deep-Sea-Derived Penicillium allii-sativi
title_sort antiproliferative sorbicillinoids from the deep-sea-derived penicillium allii-sativi
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7858254/
https://www.ncbi.nlm.nih.gov/pubmed/33552036
http://dx.doi.org/10.3389/fmicb.2020.636948
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