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The Role of Lipid Transfer Proteins as Food and Pollen Allergens Outside the Mediterranean Area
PURPOSE OF REVIEW: To provide an overview of the prevalence and clinical manifestation of non-specific lipid transfer proteins (LTP)-mediated allergies outside the Mediterranean area and to address potential reasons for the different geographical significance of LTP-driven allergies. RECENT FINDINGS...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7858557/ https://www.ncbi.nlm.nih.gov/pubmed/33537877 http://dx.doi.org/10.1007/s11882-020-00982-w |
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author | Scheurer, Stephan van Ree, Ronald Vieths, Stefan |
author_facet | Scheurer, Stephan van Ree, Ronald Vieths, Stefan |
author_sort | Scheurer, Stephan |
collection | PubMed |
description | PURPOSE OF REVIEW: To provide an overview of the prevalence and clinical manifestation of non-specific lipid transfer proteins (LTP)-mediated allergies outside the Mediterranean area and to address potential reasons for the different geographical significance of LTP-driven allergies. RECENT FINDINGS: LTPs are major allergens in the Mediterranean area, which frequently can elicit severe reactions. Pru p 3 the LTP from peach is reported as genuine allergen and is considered a prototypic marker for LTP-mediated allergies. However, both food and pollen LTP allergies exist outside the Mediterranean area, but with lower clinical significance, different immunogenicity, and less clarified role. SUMMARY: Evidence has been reported that in areas with high exposure to pollen, in particular to mugwort, pollen-derived LTPs can act as a primary sensitizer to trigger secondary food allergies. Co-sensitization to unrelated allergens might be causative for less severe reactions in response to LTPs. However, the reason for the geographical different sensitization patterns to LTPs remains unclear. |
format | Online Article Text |
id | pubmed-7858557 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-78585572021-02-11 The Role of Lipid Transfer Proteins as Food and Pollen Allergens Outside the Mediterranean Area Scheurer, Stephan van Ree, Ronald Vieths, Stefan Curr Allergy Asthma Rep Allergens (RK Bush and S Vieths, Section Editors) PURPOSE OF REVIEW: To provide an overview of the prevalence and clinical manifestation of non-specific lipid transfer proteins (LTP)-mediated allergies outside the Mediterranean area and to address potential reasons for the different geographical significance of LTP-driven allergies. RECENT FINDINGS: LTPs are major allergens in the Mediterranean area, which frequently can elicit severe reactions. Pru p 3 the LTP from peach is reported as genuine allergen and is considered a prototypic marker for LTP-mediated allergies. However, both food and pollen LTP allergies exist outside the Mediterranean area, but with lower clinical significance, different immunogenicity, and less clarified role. SUMMARY: Evidence has been reported that in areas with high exposure to pollen, in particular to mugwort, pollen-derived LTPs can act as a primary sensitizer to trigger secondary food allergies. Co-sensitization to unrelated allergens might be causative for less severe reactions in response to LTPs. However, the reason for the geographical different sensitization patterns to LTPs remains unclear. Springer US 2021-02-03 2021 /pmc/articles/PMC7858557/ /pubmed/33537877 http://dx.doi.org/10.1007/s11882-020-00982-w Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Allergens (RK Bush and S Vieths, Section Editors) Scheurer, Stephan van Ree, Ronald Vieths, Stefan The Role of Lipid Transfer Proteins as Food and Pollen Allergens Outside the Mediterranean Area |
title | The Role of Lipid Transfer Proteins as Food and Pollen Allergens Outside the Mediterranean Area |
title_full | The Role of Lipid Transfer Proteins as Food and Pollen Allergens Outside the Mediterranean Area |
title_fullStr | The Role of Lipid Transfer Proteins as Food and Pollen Allergens Outside the Mediterranean Area |
title_full_unstemmed | The Role of Lipid Transfer Proteins as Food and Pollen Allergens Outside the Mediterranean Area |
title_short | The Role of Lipid Transfer Proteins as Food and Pollen Allergens Outside the Mediterranean Area |
title_sort | role of lipid transfer proteins as food and pollen allergens outside the mediterranean area |
topic | Allergens (RK Bush and S Vieths, Section Editors) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7858557/ https://www.ncbi.nlm.nih.gov/pubmed/33537877 http://dx.doi.org/10.1007/s11882-020-00982-w |
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