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High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming

Macrophages are plastic and, in response to different local stimuli, can polarize toward multi-dimensional spectrum of phenotypes, including the pro-inflammatory M1-like and the anti-inflammatory M2-like states. Using a high-throughput phenotypic screen in a library of ~4000 FDA-approved drugs, bioa...

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Detalles Bibliográficos
Autores principales:	Hu, Guangan, Su, Yang, Kang, Byong Ha, Fan, Zhongqi, Dong, Ting, Brown, Douglas R., Cheah, Jaime, Wittrup, Karl Dane, Chen, Jianzhu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7858590/ https://www.ncbi.nlm.nih.gov/pubmed/33536439 http://dx.doi.org/10.1038/s41467-021-21066-x

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