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Deafness Weakens Interareal Couplings in the Auditory Cortex
The function of the cerebral cortex essentially depends on the ability to form functional assemblies across different cortical areas serving different functions. Here we investigated how developmental hearing experience affects functional and effective interareal connectivity in the auditory cortex...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7858676/ https://www.ncbi.nlm.nih.gov/pubmed/33551733 http://dx.doi.org/10.3389/fnins.2020.625721 |
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author | Yusuf, Prasandhya Astagiri Hubka, Peter Tillein, Jochen Vinck, Martin Kral, Andrej |
author_facet | Yusuf, Prasandhya Astagiri Hubka, Peter Tillein, Jochen Vinck, Martin Kral, Andrej |
author_sort | Yusuf, Prasandhya Astagiri |
collection | PubMed |
description | The function of the cerebral cortex essentially depends on the ability to form functional assemblies across different cortical areas serving different functions. Here we investigated how developmental hearing experience affects functional and effective interareal connectivity in the auditory cortex in an animal model with years-long and complete auditory deprivation (deafness) from birth, the congenitally deaf cat (CDC). Using intracortical multielectrode arrays, neuronal activity of adult hearing controls and CDCs was registered in the primary auditory cortex and the secondary posterior auditory field (PAF). Ongoing activity as well as responses to acoustic stimulation (in adult hearing controls) and electric stimulation applied via cochlear implants (in adult hearing controls and CDCs) were analyzed. As functional connectivity measures pairwise phase consistency and Granger causality were used. While the number of coupled sites was nearly identical between controls and CDCs, a reduced coupling strength between the primary and the higher order field was found in CDCs under auditory stimulation. Such stimulus-related decoupling was particularly pronounced in the alpha band and in top–down direction. Ongoing connectivity did not show such a decoupling. These findings suggest that developmental experience is essential for functional interareal interactions during sensory processing. The outcomes demonstrate that corticocortical couplings, particularly top-down connectivity, are compromised following congenital sensory deprivation. |
format | Online Article Text |
id | pubmed-7858676 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78586762021-02-05 Deafness Weakens Interareal Couplings in the Auditory Cortex Yusuf, Prasandhya Astagiri Hubka, Peter Tillein, Jochen Vinck, Martin Kral, Andrej Front Neurosci Neuroscience The function of the cerebral cortex essentially depends on the ability to form functional assemblies across different cortical areas serving different functions. Here we investigated how developmental hearing experience affects functional and effective interareal connectivity in the auditory cortex in an animal model with years-long and complete auditory deprivation (deafness) from birth, the congenitally deaf cat (CDC). Using intracortical multielectrode arrays, neuronal activity of adult hearing controls and CDCs was registered in the primary auditory cortex and the secondary posterior auditory field (PAF). Ongoing activity as well as responses to acoustic stimulation (in adult hearing controls) and electric stimulation applied via cochlear implants (in adult hearing controls and CDCs) were analyzed. As functional connectivity measures pairwise phase consistency and Granger causality were used. While the number of coupled sites was nearly identical between controls and CDCs, a reduced coupling strength between the primary and the higher order field was found in CDCs under auditory stimulation. Such stimulus-related decoupling was particularly pronounced in the alpha band and in top–down direction. Ongoing connectivity did not show such a decoupling. These findings suggest that developmental experience is essential for functional interareal interactions during sensory processing. The outcomes demonstrate that corticocortical couplings, particularly top-down connectivity, are compromised following congenital sensory deprivation. Frontiers Media S.A. 2021-01-21 /pmc/articles/PMC7858676/ /pubmed/33551733 http://dx.doi.org/10.3389/fnins.2020.625721 Text en Copyright © 2021 Yusuf, Hubka, Tillein, Vinck and Kral. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Yusuf, Prasandhya Astagiri Hubka, Peter Tillein, Jochen Vinck, Martin Kral, Andrej Deafness Weakens Interareal Couplings in the Auditory Cortex |
title | Deafness Weakens Interareal Couplings in the Auditory Cortex |
title_full | Deafness Weakens Interareal Couplings in the Auditory Cortex |
title_fullStr | Deafness Weakens Interareal Couplings in the Auditory Cortex |
title_full_unstemmed | Deafness Weakens Interareal Couplings in the Auditory Cortex |
title_short | Deafness Weakens Interareal Couplings in the Auditory Cortex |
title_sort | deafness weakens interareal couplings in the auditory cortex |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7858676/ https://www.ncbi.nlm.nih.gov/pubmed/33551733 http://dx.doi.org/10.3389/fnins.2020.625721 |
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