Cargando…

Dynamics in Endolymphatic Hydrops & Symptoms in Meniere's Disease After Endolymphatic Duct Blockage, Preliminary Results

Objective: The purpose of the present study was to evaluate the dynamics of endolymphatic hydrops (EH) and symptoms in a group of patients who underwent endolymphatic duct blockage (EDB) for treatment of intractable Meniere's Disease (MD), and to explore a metric for verifying the effectiveness...

Descripción completa

Detalles Bibliográficos
Autores principales: He, Jun, Peng, Anquan, Hu, Junjiao, Zhang, Zhiwen, Chen, Yichao, Wang, Qin, Liu, Wei, Chao, Huang, Deng, Kai, Jiang, Wenqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859097/
https://www.ncbi.nlm.nih.gov/pubmed/33551977
http://dx.doi.org/10.3389/fneur.2020.622760
_version_ 1783646660958617600
author He, Jun
Peng, Anquan
Hu, Junjiao
Zhang, Zhiwen
Chen, Yichao
Wang, Qin
Liu, Wei
Chao, Huang
Deng, Kai
Jiang, Wenqi
author_facet He, Jun
Peng, Anquan
Hu, Junjiao
Zhang, Zhiwen
Chen, Yichao
Wang, Qin
Liu, Wei
Chao, Huang
Deng, Kai
Jiang, Wenqi
author_sort He, Jun
collection PubMed
description Objective: The purpose of the present study was to evaluate the dynamics of endolymphatic hydrops (EH) and symptoms in a group of patients who underwent endolymphatic duct blockage (EDB) for treatment of intractable Meniere's Disease (MD), and to explore a metric for verifying the effectiveness of EDB procedure. Methods: A total of 22 patients with intractable MD patients who underwent EDB participated in the present study. EH was visualized using locally enhanced inner ear magnetic resonance imaging (MRI) prior to and following surgery. The vestibular hydrops ratio (VHR) in the second MRI examination was compared with the pre-surgery recordings. Results: Following EDB, 6 patients exhibited complete or partial reversal of EH, complete control of vertigo spells and reported improvement in hearing; 13 patients showed no changes in EH or hearing, but 5 of these patients exhibited complete control of vertigo attacks, and the other 8 patients exhibited improved control of vertigo attacks. The final 3 patients showed an increase in EH, but symptomatic worsening in 2 patients, and symptomatic improvement in 1 patient. There was a significant difference in the average VHR prior to and following EDB. Postoperative VHR was positively correlated with the frequency of vertigo spells in the latest 6 months of follow-up and improvement of postoperative average hearing threshold. Conclusion: The decreased EH accompanying the reduction in vertigo attacks and hearing preservation may provide a metric for verifying the effectiveness of EDB treatment in patients with MD.
format Online
Article
Text
id pubmed-7859097
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-78590972021-02-05 Dynamics in Endolymphatic Hydrops & Symptoms in Meniere's Disease After Endolymphatic Duct Blockage, Preliminary Results He, Jun Peng, Anquan Hu, Junjiao Zhang, Zhiwen Chen, Yichao Wang, Qin Liu, Wei Chao, Huang Deng, Kai Jiang, Wenqi Front Neurol Neurology Objective: The purpose of the present study was to evaluate the dynamics of endolymphatic hydrops (EH) and symptoms in a group of patients who underwent endolymphatic duct blockage (EDB) for treatment of intractable Meniere's Disease (MD), and to explore a metric for verifying the effectiveness of EDB procedure. Methods: A total of 22 patients with intractable MD patients who underwent EDB participated in the present study. EH was visualized using locally enhanced inner ear magnetic resonance imaging (MRI) prior to and following surgery. The vestibular hydrops ratio (VHR) in the second MRI examination was compared with the pre-surgery recordings. Results: Following EDB, 6 patients exhibited complete or partial reversal of EH, complete control of vertigo spells and reported improvement in hearing; 13 patients showed no changes in EH or hearing, but 5 of these patients exhibited complete control of vertigo attacks, and the other 8 patients exhibited improved control of vertigo attacks. The final 3 patients showed an increase in EH, but symptomatic worsening in 2 patients, and symptomatic improvement in 1 patient. There was a significant difference in the average VHR prior to and following EDB. Postoperative VHR was positively correlated with the frequency of vertigo spells in the latest 6 months of follow-up and improvement of postoperative average hearing threshold. Conclusion: The decreased EH accompanying the reduction in vertigo attacks and hearing preservation may provide a metric for verifying the effectiveness of EDB treatment in patients with MD. Frontiers Media S.A. 2021-01-21 /pmc/articles/PMC7859097/ /pubmed/33551977 http://dx.doi.org/10.3389/fneur.2020.622760 Text en Copyright © 2021 He, Peng, Hu, Zhang, Chen, Wang, Liu, Chao, Deng and Jiang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
He, Jun
Peng, Anquan
Hu, Junjiao
Zhang, Zhiwen
Chen, Yichao
Wang, Qin
Liu, Wei
Chao, Huang
Deng, Kai
Jiang, Wenqi
Dynamics in Endolymphatic Hydrops & Symptoms in Meniere's Disease After Endolymphatic Duct Blockage, Preliminary Results
title Dynamics in Endolymphatic Hydrops & Symptoms in Meniere's Disease After Endolymphatic Duct Blockage, Preliminary Results
title_full Dynamics in Endolymphatic Hydrops & Symptoms in Meniere's Disease After Endolymphatic Duct Blockage, Preliminary Results
title_fullStr Dynamics in Endolymphatic Hydrops & Symptoms in Meniere's Disease After Endolymphatic Duct Blockage, Preliminary Results
title_full_unstemmed Dynamics in Endolymphatic Hydrops & Symptoms in Meniere's Disease After Endolymphatic Duct Blockage, Preliminary Results
title_short Dynamics in Endolymphatic Hydrops & Symptoms in Meniere's Disease After Endolymphatic Duct Blockage, Preliminary Results
title_sort dynamics in endolymphatic hydrops & symptoms in meniere's disease after endolymphatic duct blockage, preliminary results
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859097/
https://www.ncbi.nlm.nih.gov/pubmed/33551977
http://dx.doi.org/10.3389/fneur.2020.622760
work_keys_str_mv AT hejun dynamicsinendolymphatichydropssymptomsinmenieresdiseaseafterendolymphaticductblockagepreliminaryresults
AT penganquan dynamicsinendolymphatichydropssymptomsinmenieresdiseaseafterendolymphaticductblockagepreliminaryresults
AT hujunjiao dynamicsinendolymphatichydropssymptomsinmenieresdiseaseafterendolymphaticductblockagepreliminaryresults
AT zhangzhiwen dynamicsinendolymphatichydropssymptomsinmenieresdiseaseafterendolymphaticductblockagepreliminaryresults
AT chenyichao dynamicsinendolymphatichydropssymptomsinmenieresdiseaseafterendolymphaticductblockagepreliminaryresults
AT wangqin dynamicsinendolymphatichydropssymptomsinmenieresdiseaseafterendolymphaticductblockagepreliminaryresults
AT liuwei dynamicsinendolymphatichydropssymptomsinmenieresdiseaseafterendolymphaticductblockagepreliminaryresults
AT chaohuang dynamicsinendolymphatichydropssymptomsinmenieresdiseaseafterendolymphaticductblockagepreliminaryresults
AT dengkai dynamicsinendolymphatichydropssymptomsinmenieresdiseaseafterendolymphaticductblockagepreliminaryresults
AT jiangwenqi dynamicsinendolymphatichydropssymptomsinmenieresdiseaseafterendolymphaticductblockagepreliminaryresults