Regulatory Role of the RNA N(6)-Methyladenosine Modification in Immunoregulatory Cells and Immune-Related Bone Homeostasis Associated With Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a systemic autoimmune disease for which the etiology has not been fully elucidated. Previous studies have shown that the development of RA has genetic and epigenetic components. As one of the most highly abundant RNA modifications, the N(6)-methyladenosine (m(6)A) modification is necessary for the biogenesis and functioning of RNA, and modification aberrancies are associated with various diseases. However, the specific functions of m(6)A in the cellular processes of RA remain unclear. Recent studies have revealed the relationship between m(6)A modification and immune cells associated with RA. Therefore, in this review, we focused on discussing the functions of m(6)A modification in the regulation of immune cells and immune-related bone homeostasis associated with RA. In addition, to gain a better understanding of the progress in this field of study and provide the proper direction and suggestions for further study, clinical application studies of m(6)A modification were also summarized.