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Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis
The triggering receptor expressed on myeloid cells 1 (TREM-1) and peptidoglycan recognition protein 1 (PGLYRP1) are involved in the propagation of inflammatory responses. This study investigated whether serum levels of TREM-1 and PGLYRP1 correlate with periodontitis in rheumatoid arthritis (RA) pati...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859204/ https://www.ncbi.nlm.nih.gov/pubmed/33536478 http://dx.doi.org/10.1038/s41598-021-82335-9 |
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author | Inanc, Nevsun Mumcu, Gonca Can, Meryem Yay, Meral Silbereisen, Angelika Manoil, Daniel Direskeneli, Haner Bostanci, Nagihan |
author_facet | Inanc, Nevsun Mumcu, Gonca Can, Meryem Yay, Meral Silbereisen, Angelika Manoil, Daniel Direskeneli, Haner Bostanci, Nagihan |
author_sort | Inanc, Nevsun |
collection | PubMed |
description | The triggering receptor expressed on myeloid cells 1 (TREM-1) and peptidoglycan recognition protein 1 (PGLYRP1) are involved in the propagation of inflammatory responses. This study investigated whether serum levels of TREM-1 and PGLYRP1 correlate with periodontitis in rheumatoid arthritis (RA) patients. A total of 154 non-smoking participants with RA (n = 55, F/M: 41/14), Behçet´s disease (BD, n = 41, F/M: 30/11) and healthy controls (HC, n = 58, F/M: 40/18) were recruited. Serum and saliva were collected, the 28-joint disease activity score (DAS-28) was calculated and dental/periodontal measurements were recorded. Serum TREM-1 and PGLYRP1 levels were measured by ELISA and salivary bacterial DNA counts by quantitative polymerase chain reaction. TREM-1 and PGLYRP1 levels were higher in RA (166.3 ± 94.3; 155.5 ± 226.9 pg/ml) than BD (102.3 ± 42.8; 52.5 ± 26.3 pg/ml) and HCs (89.8 ± 55.7; 67.4 ± 37.3 pg/ml) (p < 0.05). In RA, periodontitis was associated with increased TREM-1 and PGLYRP1 levels (p < 0.05), yet in patients under methotrexate TREM-1 levels were lower. TREM-1 correlated with C-reactive protein (CRP) levels, DAS-28 and erythrocyte sedimentation rate, whereas PGLYRP1 positively correlated with CRP. RA patients displayed 3.5-fold higher salivary bacterial DNA counts than HCs. Increased serum TREM-1 levels correlated with PGLYRP1, CRP and DAS-28-ESR in RA patients with periodontitis. |
format | Online Article Text |
id | pubmed-7859204 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78592042021-02-04 Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis Inanc, Nevsun Mumcu, Gonca Can, Meryem Yay, Meral Silbereisen, Angelika Manoil, Daniel Direskeneli, Haner Bostanci, Nagihan Sci Rep Article The triggering receptor expressed on myeloid cells 1 (TREM-1) and peptidoglycan recognition protein 1 (PGLYRP1) are involved in the propagation of inflammatory responses. This study investigated whether serum levels of TREM-1 and PGLYRP1 correlate with periodontitis in rheumatoid arthritis (RA) patients. A total of 154 non-smoking participants with RA (n = 55, F/M: 41/14), Behçet´s disease (BD, n = 41, F/M: 30/11) and healthy controls (HC, n = 58, F/M: 40/18) were recruited. Serum and saliva were collected, the 28-joint disease activity score (DAS-28) was calculated and dental/periodontal measurements were recorded. Serum TREM-1 and PGLYRP1 levels were measured by ELISA and salivary bacterial DNA counts by quantitative polymerase chain reaction. TREM-1 and PGLYRP1 levels were higher in RA (166.3 ± 94.3; 155.5 ± 226.9 pg/ml) than BD (102.3 ± 42.8; 52.5 ± 26.3 pg/ml) and HCs (89.8 ± 55.7; 67.4 ± 37.3 pg/ml) (p < 0.05). In RA, periodontitis was associated with increased TREM-1 and PGLYRP1 levels (p < 0.05), yet in patients under methotrexate TREM-1 levels were lower. TREM-1 correlated with C-reactive protein (CRP) levels, DAS-28 and erythrocyte sedimentation rate, whereas PGLYRP1 positively correlated with CRP. RA patients displayed 3.5-fold higher salivary bacterial DNA counts than HCs. Increased serum TREM-1 levels correlated with PGLYRP1, CRP and DAS-28-ESR in RA patients with periodontitis. Nature Publishing Group UK 2021-02-03 /pmc/articles/PMC7859204/ /pubmed/33536478 http://dx.doi.org/10.1038/s41598-021-82335-9 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Inanc, Nevsun Mumcu, Gonca Can, Meryem Yay, Meral Silbereisen, Angelika Manoil, Daniel Direskeneli, Haner Bostanci, Nagihan Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis |
title | Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis |
title_full | Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis |
title_fullStr | Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis |
title_full_unstemmed | Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis |
title_short | Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis |
title_sort | elevated serum trem-1 is associated with periodontitis and disease activity in rheumatoid arthritis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859204/ https://www.ncbi.nlm.nih.gov/pubmed/33536478 http://dx.doi.org/10.1038/s41598-021-82335-9 |
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