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Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis

The triggering receptor expressed on myeloid cells 1 (TREM-1) and peptidoglycan recognition protein 1 (PGLYRP1) are involved in the propagation of inflammatory responses. This study investigated whether serum levels of TREM-1 and PGLYRP1 correlate with periodontitis in rheumatoid arthritis (RA) pati...

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Autores principales: Inanc, Nevsun, Mumcu, Gonca, Can, Meryem, Yay, Meral, Silbereisen, Angelika, Manoil, Daniel, Direskeneli, Haner, Bostanci, Nagihan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859204/
https://www.ncbi.nlm.nih.gov/pubmed/33536478
http://dx.doi.org/10.1038/s41598-021-82335-9
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author Inanc, Nevsun
Mumcu, Gonca
Can, Meryem
Yay, Meral
Silbereisen, Angelika
Manoil, Daniel
Direskeneli, Haner
Bostanci, Nagihan
author_facet Inanc, Nevsun
Mumcu, Gonca
Can, Meryem
Yay, Meral
Silbereisen, Angelika
Manoil, Daniel
Direskeneli, Haner
Bostanci, Nagihan
author_sort Inanc, Nevsun
collection PubMed
description The triggering receptor expressed on myeloid cells 1 (TREM-1) and peptidoglycan recognition protein 1 (PGLYRP1) are involved in the propagation of inflammatory responses. This study investigated whether serum levels of TREM-1 and PGLYRP1 correlate with periodontitis in rheumatoid arthritis (RA) patients. A total of 154 non-smoking participants with RA (n = 55, F/M: 41/14), Behçet´s disease (BD, n = 41, F/M: 30/11) and healthy controls (HC, n = 58, F/M: 40/18) were recruited. Serum and saliva were collected, the 28-joint disease activity score (DAS-28) was calculated and dental/periodontal measurements were recorded. Serum TREM-1 and PGLYRP1 levels were measured by ELISA and salivary bacterial DNA counts by quantitative polymerase chain reaction. TREM-1 and PGLYRP1 levels were higher in RA (166.3 ± 94.3; 155.5 ± 226.9 pg/ml) than BD (102.3 ± 42.8; 52.5 ± 26.3 pg/ml) and HCs (89.8 ± 55.7; 67.4 ± 37.3 pg/ml) (p < 0.05). In RA, periodontitis was associated with increased TREM-1 and PGLYRP1 levels (p < 0.05), yet in patients under methotrexate TREM-1 levels were lower. TREM-1 correlated with C-reactive protein (CRP) levels, DAS-28 and erythrocyte sedimentation rate, whereas PGLYRP1 positively correlated with CRP. RA patients displayed 3.5-fold higher salivary bacterial DNA counts than HCs. Increased serum TREM-1 levels correlated with PGLYRP1, CRP and DAS-28-ESR in RA patients with periodontitis.
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spelling pubmed-78592042021-02-04 Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis Inanc, Nevsun Mumcu, Gonca Can, Meryem Yay, Meral Silbereisen, Angelika Manoil, Daniel Direskeneli, Haner Bostanci, Nagihan Sci Rep Article The triggering receptor expressed on myeloid cells 1 (TREM-1) and peptidoglycan recognition protein 1 (PGLYRP1) are involved in the propagation of inflammatory responses. This study investigated whether serum levels of TREM-1 and PGLYRP1 correlate with periodontitis in rheumatoid arthritis (RA) patients. A total of 154 non-smoking participants with RA (n = 55, F/M: 41/14), Behçet´s disease (BD, n = 41, F/M: 30/11) and healthy controls (HC, n = 58, F/M: 40/18) were recruited. Serum and saliva were collected, the 28-joint disease activity score (DAS-28) was calculated and dental/periodontal measurements were recorded. Serum TREM-1 and PGLYRP1 levels were measured by ELISA and salivary bacterial DNA counts by quantitative polymerase chain reaction. TREM-1 and PGLYRP1 levels were higher in RA (166.3 ± 94.3; 155.5 ± 226.9 pg/ml) than BD (102.3 ± 42.8; 52.5 ± 26.3 pg/ml) and HCs (89.8 ± 55.7; 67.4 ± 37.3 pg/ml) (p < 0.05). In RA, periodontitis was associated with increased TREM-1 and PGLYRP1 levels (p < 0.05), yet in patients under methotrexate TREM-1 levels were lower. TREM-1 correlated with C-reactive protein (CRP) levels, DAS-28 and erythrocyte sedimentation rate, whereas PGLYRP1 positively correlated with CRP. RA patients displayed 3.5-fold higher salivary bacterial DNA counts than HCs. Increased serum TREM-1 levels correlated with PGLYRP1, CRP and DAS-28-ESR in RA patients with periodontitis. Nature Publishing Group UK 2021-02-03 /pmc/articles/PMC7859204/ /pubmed/33536478 http://dx.doi.org/10.1038/s41598-021-82335-9 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Inanc, Nevsun
Mumcu, Gonca
Can, Meryem
Yay, Meral
Silbereisen, Angelika
Manoil, Daniel
Direskeneli, Haner
Bostanci, Nagihan
Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis
title Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis
title_full Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis
title_fullStr Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis
title_full_unstemmed Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis
title_short Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis
title_sort elevated serum trem-1 is associated with periodontitis and disease activity in rheumatoid arthritis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859204/
https://www.ncbi.nlm.nih.gov/pubmed/33536478
http://dx.doi.org/10.1038/s41598-021-82335-9
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