Arrayed CRISPR reveals genetic regulators of tau aggregation, autophagy and mitochondria in Alzheimer’s disease model

Alzheimer’s disease (AD) is a common neurodegenerative disease with poor prognosis. New options for drug discovery targets are needed. We developed an imaging based arrayed CRISPR method to interrogate the human genome for modulation of in vitro correlates of AD features, and used this to assess 152...

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Detalles Bibliográficos
Autores principales: Duan, Lishu, Hu, Mufeng, Tamm, Joseph A., Grinberg, Yelena Y., Shen, Fang, Chai, Yating, Xi, Hualin, Gibilisco, Lauren, Ravikumar, Brinda, Gautam, Vivek, Karran, Eric, Townsend, Matthew, Talanian, Robert V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859211/
https://www.ncbi.nlm.nih.gov/pubmed/33536571
http://dx.doi.org/10.1038/s41598-021-82658-7

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