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GLP-1 and hunger modulate incentive motivation depending on insulin sensitivity in humans

OBJECTIVE: To regulate food intake, our brain constantly integrates external cues, such as the incentive value of a potential food reward, with internal state signals, such as hunger feelings. Incentive motivation refers to the processes that translate an expected reward into the effort spent to obt...

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Autores principales: Hanssen, Ruth, Kretschmer, Alina Chloé, Rigoux, Lionel, Albus, Kerstin, Edwin Thanarajah, Sharmili, Sitnikow, Tamara, Melzer, Corina, Cornely, Oliver A., Brüning, Jens C., Tittgemeyer, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859312/
https://www.ncbi.nlm.nih.gov/pubmed/33453418
http://dx.doi.org/10.1016/j.molmet.2021.101163
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author Hanssen, Ruth
Kretschmer, Alina Chloé
Rigoux, Lionel
Albus, Kerstin
Edwin Thanarajah, Sharmili
Sitnikow, Tamara
Melzer, Corina
Cornely, Oliver A.
Brüning, Jens C.
Tittgemeyer, Marc
author_facet Hanssen, Ruth
Kretschmer, Alina Chloé
Rigoux, Lionel
Albus, Kerstin
Edwin Thanarajah, Sharmili
Sitnikow, Tamara
Melzer, Corina
Cornely, Oliver A.
Brüning, Jens C.
Tittgemeyer, Marc
author_sort Hanssen, Ruth
collection PubMed
description OBJECTIVE: To regulate food intake, our brain constantly integrates external cues, such as the incentive value of a potential food reward, with internal state signals, such as hunger feelings. Incentive motivation refers to the processes that translate an expected reward into the effort spent to obtain the reward; the magnitude and probability of a reward involved in prompting motivated behaviour are encoded by the dopaminergic (DA) midbrain and its mesoaccumbens DA projections. This type of reward circuity is particularly sensitive to the metabolic state signalled by peripheral mediators, such as insulin or glucagon-like peptide 1 (GLP-1). While in rodents the modulatory effect of metabolic state signals on motivated behaviour is well documented, evidence of state-dependent modulation and the role of incentive motivation underlying overeating in humans is lacking. METHODS: In a randomised, placebo-controlled, crossover design, 21 lean (body mass index [BMI] < 25 kg/m(2)) and 16 obese (BMI³ 30 kg/m(2)) volunteer participants received either liraglutide as a GLP-1 analogue or placebo on two separate testing days. Incentive motivation was measured using a behavioural task in which participants were required to exert physical effort using a handgrip to win different amounts of food and monetary rewards. Hunger levels were measured using visual analogue scales; insulin, glucose, and systemic insulin resistance as assessed by the homeostasis model assessment of insulin resistance (HOMA-IR) were quantified at baseline. RESULTS: In this report, we demonstrate that incentive motivation increases with hunger in lean humans (F((1,42)) = 5.31, p = 0.026, β = 0.19) independently of incentive type (food and non-food reward). This effect of hunger is not evident in obese humans (F((1,62)) = 1.93, p = 0.17, β = −0.12). Motivational drive related to hunger is affected by peripheral insulin sensitivity (two-way interaction, F((1, 35)) = 6.23, p = 0.017, β = −0.281). In humans with higher insulin sensitivity, hunger increases motivation, while poorer insulin sensitivity dampens the motivational effect of hunger. The GLP-1 analogue application blunts the interaction effect of hunger on motivation depending on insulin sensitivity (three-way interaction, F((1, 127)) = 5.11, p = 0.026); no difference in motivated behaviour could be found between humans with normal or impaired insulin sensitivity under GLP-1 administration. CONCLUSION: We report a differential effect of hunger on motivation depending on insulin sensitivity. We further revealed the modulatory role of GLP-1 in adaptive, motivated behaviour in humans and its interaction with peripheral insulin sensitivity and hunger. Our results suggest that GLP-1 might restore dysregulated processes of midbrain DA function and hence motivational behaviour in insulin-resistant humans.
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spelling pubmed-78593122021-02-05 GLP-1 and hunger modulate incentive motivation depending on insulin sensitivity in humans Hanssen, Ruth Kretschmer, Alina Chloé Rigoux, Lionel Albus, Kerstin Edwin Thanarajah, Sharmili Sitnikow, Tamara Melzer, Corina Cornely, Oliver A. Brüning, Jens C. Tittgemeyer, Marc Mol Metab Brief Communication OBJECTIVE: To regulate food intake, our brain constantly integrates external cues, such as the incentive value of a potential food reward, with internal state signals, such as hunger feelings. Incentive motivation refers to the processes that translate an expected reward into the effort spent to obtain the reward; the magnitude and probability of a reward involved in prompting motivated behaviour are encoded by the dopaminergic (DA) midbrain and its mesoaccumbens DA projections. This type of reward circuity is particularly sensitive to the metabolic state signalled by peripheral mediators, such as insulin or glucagon-like peptide 1 (GLP-1). While in rodents the modulatory effect of metabolic state signals on motivated behaviour is well documented, evidence of state-dependent modulation and the role of incentive motivation underlying overeating in humans is lacking. METHODS: In a randomised, placebo-controlled, crossover design, 21 lean (body mass index [BMI] < 25 kg/m(2)) and 16 obese (BMI³ 30 kg/m(2)) volunteer participants received either liraglutide as a GLP-1 analogue or placebo on two separate testing days. Incentive motivation was measured using a behavioural task in which participants were required to exert physical effort using a handgrip to win different amounts of food and monetary rewards. Hunger levels were measured using visual analogue scales; insulin, glucose, and systemic insulin resistance as assessed by the homeostasis model assessment of insulin resistance (HOMA-IR) were quantified at baseline. RESULTS: In this report, we demonstrate that incentive motivation increases with hunger in lean humans (F((1,42)) = 5.31, p = 0.026, β = 0.19) independently of incentive type (food and non-food reward). This effect of hunger is not evident in obese humans (F((1,62)) = 1.93, p = 0.17, β = −0.12). Motivational drive related to hunger is affected by peripheral insulin sensitivity (two-way interaction, F((1, 35)) = 6.23, p = 0.017, β = −0.281). In humans with higher insulin sensitivity, hunger increases motivation, while poorer insulin sensitivity dampens the motivational effect of hunger. The GLP-1 analogue application blunts the interaction effect of hunger on motivation depending on insulin sensitivity (three-way interaction, F((1, 127)) = 5.11, p = 0.026); no difference in motivated behaviour could be found between humans with normal or impaired insulin sensitivity under GLP-1 administration. CONCLUSION: We report a differential effect of hunger on motivation depending on insulin sensitivity. We further revealed the modulatory role of GLP-1 in adaptive, motivated behaviour in humans and its interaction with peripheral insulin sensitivity and hunger. Our results suggest that GLP-1 might restore dysregulated processes of midbrain DA function and hence motivational behaviour in insulin-resistant humans. Elsevier 2021-01-14 /pmc/articles/PMC7859312/ /pubmed/33453418 http://dx.doi.org/10.1016/j.molmet.2021.101163 Text en © 2021 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Brief Communication
Hanssen, Ruth
Kretschmer, Alina Chloé
Rigoux, Lionel
Albus, Kerstin
Edwin Thanarajah, Sharmili
Sitnikow, Tamara
Melzer, Corina
Cornely, Oliver A.
Brüning, Jens C.
Tittgemeyer, Marc
GLP-1 and hunger modulate incentive motivation depending on insulin sensitivity in humans
title GLP-1 and hunger modulate incentive motivation depending on insulin sensitivity in humans
title_full GLP-1 and hunger modulate incentive motivation depending on insulin sensitivity in humans
title_fullStr GLP-1 and hunger modulate incentive motivation depending on insulin sensitivity in humans
title_full_unstemmed GLP-1 and hunger modulate incentive motivation depending on insulin sensitivity in humans
title_short GLP-1 and hunger modulate incentive motivation depending on insulin sensitivity in humans
title_sort glp-1 and hunger modulate incentive motivation depending on insulin sensitivity in humans
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859312/
https://www.ncbi.nlm.nih.gov/pubmed/33453418
http://dx.doi.org/10.1016/j.molmet.2021.101163
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