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Role of B lymphocytes in the infarcted mass in patients with acute myocardial infarction

Despite early reperfusion, patients with ST segment elevation myocardial infarction (STEMI) may present large myocardial necrosis and significant impairment of ventricular function. The present study aimed to evaluate the role of subtypes of B lymphocytes and related cytokines in the infarcted mass...

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Autores principales: Casarotti, Ana C.A., Teixeira, Daniela, Longo-Maugeri, Ieda M., Ishimura, Mayari E., Coste, Maria E.R., Bianco, Henrique T., Moreira, Flavio T., Bacchin, Amanda F., Izar, Maria C., Gonçalves, Iran, Caixeta, Adriano, Szarf, Gilberto, Pinto, Ibraim M., Fonseca, Francisco A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859321/
https://www.ncbi.nlm.nih.gov/pubmed/33495783
http://dx.doi.org/10.1042/BSR20203413
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author Casarotti, Ana C.A.
Teixeira, Daniela
Longo-Maugeri, Ieda M.
Ishimura, Mayari E.
Coste, Maria E.R.
Bianco, Henrique T.
Moreira, Flavio T.
Bacchin, Amanda F.
Izar, Maria C.
Gonçalves, Iran
Caixeta, Adriano
Szarf, Gilberto
Pinto, Ibraim M.
Fonseca, Francisco A.
author_facet Casarotti, Ana C.A.
Teixeira, Daniela
Longo-Maugeri, Ieda M.
Ishimura, Mayari E.
Coste, Maria E.R.
Bianco, Henrique T.
Moreira, Flavio T.
Bacchin, Amanda F.
Izar, Maria C.
Gonçalves, Iran
Caixeta, Adriano
Szarf, Gilberto
Pinto, Ibraim M.
Fonseca, Francisco A.
author_sort Casarotti, Ana C.A.
collection PubMed
description Despite early reperfusion, patients with ST segment elevation myocardial infarction (STEMI) may present large myocardial necrosis and significant impairment of ventricular function. The present study aimed to evaluate the role of subtypes of B lymphocytes and related cytokines in the infarcted mass and left ventricular ejection fraction obtained by cardiac magnetic resonance imaging performed after 30 days of STEMI. This prospective study included 120 subjects with STEMI submitted to pharmacoinvasive strategy. Blood samples were collected in subjects in the first (D1) and 30th (D30) days post STEMI. The amount of CD11b+ B1 lymphocytes (cells/ml) at D1 were related to the infarcted mass (rho = 0.43; P=0.033), measured by cardiac MRI at D30. These B1 cells were associated with CD4+ T lymphocytes at D1 and D30, while B2 classic lymphocytes at day 30 were related to left ventricular ejection fraction (LVEF). Higher titers of circulating IL-4 and IL-10 were observed at D30 versus D1 (P=0.013 and P<0.001, respectively). Titers of IL-6 at D1 were associated with infarcted mass (rho = 0.41, P<0.001) and inversely related to LVEF (rho = −0.38, P<0.001). After multiple linear regression analysis, high-sensitivity troponin T and IL-6 collected at day 1 were independent predictors of infarcted mass and, at day 30, only HDL-C. Regarding LVEF, high-sensitivity troponin T and high-sensitivity C-reactive protein were independent predictors at day 1, and B2 classic lymphocytes, at day 30. In subjects with STEMI, despite early reperfusion, the amount of infarcted mass and ventricular performance were related to inflammatory responses triggered by circulating B lymphocytes.
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spelling pubmed-78593212021-02-09 Role of B lymphocytes in the infarcted mass in patients with acute myocardial infarction Casarotti, Ana C.A. Teixeira, Daniela Longo-Maugeri, Ieda M. Ishimura, Mayari E. Coste, Maria E.R. Bianco, Henrique T. Moreira, Flavio T. Bacchin, Amanda F. Izar, Maria C. Gonçalves, Iran Caixeta, Adriano Szarf, Gilberto Pinto, Ibraim M. Fonseca, Francisco A. Biosci Rep Cardiovascular System & Vascular Biology Despite early reperfusion, patients with ST segment elevation myocardial infarction (STEMI) may present large myocardial necrosis and significant impairment of ventricular function. The present study aimed to evaluate the role of subtypes of B lymphocytes and related cytokines in the infarcted mass and left ventricular ejection fraction obtained by cardiac magnetic resonance imaging performed after 30 days of STEMI. This prospective study included 120 subjects with STEMI submitted to pharmacoinvasive strategy. Blood samples were collected in subjects in the first (D1) and 30th (D30) days post STEMI. The amount of CD11b+ B1 lymphocytes (cells/ml) at D1 were related to the infarcted mass (rho = 0.43; P=0.033), measured by cardiac MRI at D30. These B1 cells were associated with CD4+ T lymphocytes at D1 and D30, while B2 classic lymphocytes at day 30 were related to left ventricular ejection fraction (LVEF). Higher titers of circulating IL-4 and IL-10 were observed at D30 versus D1 (P=0.013 and P<0.001, respectively). Titers of IL-6 at D1 were associated with infarcted mass (rho = 0.41, P<0.001) and inversely related to LVEF (rho = −0.38, P<0.001). After multiple linear regression analysis, high-sensitivity troponin T and IL-6 collected at day 1 were independent predictors of infarcted mass and, at day 30, only HDL-C. Regarding LVEF, high-sensitivity troponin T and high-sensitivity C-reactive protein were independent predictors at day 1, and B2 classic lymphocytes, at day 30. In subjects with STEMI, despite early reperfusion, the amount of infarcted mass and ventricular performance were related to inflammatory responses triggered by circulating B lymphocytes. Portland Press Ltd. 2021-02-03 /pmc/articles/PMC7859321/ /pubmed/33495783 http://dx.doi.org/10.1042/BSR20203413 Text en © 2021 The Author(s). https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Cardiovascular System & Vascular Biology
Casarotti, Ana C.A.
Teixeira, Daniela
Longo-Maugeri, Ieda M.
Ishimura, Mayari E.
Coste, Maria E.R.
Bianco, Henrique T.
Moreira, Flavio T.
Bacchin, Amanda F.
Izar, Maria C.
Gonçalves, Iran
Caixeta, Adriano
Szarf, Gilberto
Pinto, Ibraim M.
Fonseca, Francisco A.
Role of B lymphocytes in the infarcted mass in patients with acute myocardial infarction
title Role of B lymphocytes in the infarcted mass in patients with acute myocardial infarction
title_full Role of B lymphocytes in the infarcted mass in patients with acute myocardial infarction
title_fullStr Role of B lymphocytes in the infarcted mass in patients with acute myocardial infarction
title_full_unstemmed Role of B lymphocytes in the infarcted mass in patients with acute myocardial infarction
title_short Role of B lymphocytes in the infarcted mass in patients with acute myocardial infarction
title_sort role of b lymphocytes in the infarcted mass in patients with acute myocardial infarction
topic Cardiovascular System & Vascular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859321/
https://www.ncbi.nlm.nih.gov/pubmed/33495783
http://dx.doi.org/10.1042/BSR20203413
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