The role of EMT-related lncRNA in the process of triple-negative breast cancer metastasis

Triple-negative breast cancer (TNBC) is the most malignant and fatal subtype of breast cancer, which has characterized by negativity expression of ER, PR, and HER2. Metastasis is the main factor affecting the prognosis of TNBC, and the process of metastasis is related to abnormal activation of epith...

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Detalles Bibliográficos
Autores principales: Zhang, Haomeng, Wang, Jiao, Yin, Yulong, Meng, Qingjie, Lyu, Yonggang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2021
Materias:
Cancer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859322/
https://www.ncbi.nlm.nih.gov/pubmed/33443534
http://dx.doi.org/10.1042/BSR20203121
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author Zhang, Haomeng
Wang, Jiao
Yin, Yulong
Meng, Qingjie
Lyu, Yonggang
author_facet Zhang, Haomeng
Wang, Jiao
Yin, Yulong
Meng, Qingjie
Lyu, Yonggang
author_sort Zhang, Haomeng
collection PubMed
description Triple-negative breast cancer (TNBC) is the most malignant and fatal subtype of breast cancer, which has characterized by negativity expression of ER, PR, and HER2. Metastasis is the main factor affecting the prognosis of TNBC, and the process of metastasis is related to abnormal activation of epithelial–mesenchymal transition (EMT). Recent studies have shown that long non-coding RNA (LncRNA) plays an important role in regulating the metastasis and invasion of TNBC. Therefore, based on the metastasis-related EMT signaling pathway, great efforts have confirmed that LncRNA is involved in the molecular mechanism of TNBC metastasis, which will provide new strategies to improve the treatment and prognosis of TNBC. In this review, we summarized many signal pathways related to EMT involved in the transfer process. The advances from the most recent studies of lncRNAs in the EMT-related signal pathways of TNBC metastasis. We also discussed the clinical research, application, and challenges of LncRNA in TNBC.
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spelling pubmed-78593222021-02-09 The role of EMT-related lncRNA in the process of triple-negative breast cancer metastasis Zhang, Haomeng Wang, Jiao Yin, Yulong Meng, Qingjie Lyu, Yonggang Biosci Rep Cancer Triple-negative breast cancer (TNBC) is the most malignant and fatal subtype of breast cancer, which has characterized by negativity expression of ER, PR, and HER2. Metastasis is the main factor affecting the prognosis of TNBC, and the process of metastasis is related to abnormal activation of epithelial–mesenchymal transition (EMT). Recent studies have shown that long non-coding RNA (LncRNA) plays an important role in regulating the metastasis and invasion of TNBC. Therefore, based on the metastasis-related EMT signaling pathway, great efforts have confirmed that LncRNA is involved in the molecular mechanism of TNBC metastasis, which will provide new strategies to improve the treatment and prognosis of TNBC. In this review, we summarized many signal pathways related to EMT involved in the transfer process. The advances from the most recent studies of lncRNAs in the EMT-related signal pathways of TNBC metastasis. We also discussed the clinical research, application, and challenges of LncRNA in TNBC. Portland Press Ltd. 2021-02-03 /pmc/articles/PMC7859322/ /pubmed/33443534 http://dx.doi.org/10.1042/BSR20203121 Text en © 2021 The Author(s). https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Cancer
Zhang, Haomeng
Wang, Jiao
Yin, Yulong
Meng, Qingjie
Lyu, Yonggang
The role of EMT-related lncRNA in the process of triple-negative breast cancer metastasis
title The role of EMT-related lncRNA in the process of triple-negative breast cancer metastasis
title_full The role of EMT-related lncRNA in the process of triple-negative breast cancer metastasis
title_fullStr The role of EMT-related lncRNA in the process of triple-negative breast cancer metastasis
title_full_unstemmed The role of EMT-related lncRNA in the process of triple-negative breast cancer metastasis
title_short The role of EMT-related lncRNA in the process of triple-negative breast cancer metastasis
title_sort role of emt-related lncrna in the process of triple-negative breast cancer metastasis
topic Cancer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859322/
https://www.ncbi.nlm.nih.gov/pubmed/33443534
http://dx.doi.org/10.1042/BSR20203121
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