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Cilomilast Ameliorates Renal Tubulointerstitial Fibrosis by Inhibiting the TGF-β1-Smad2/3 Signaling Pathway

Background: Renal tubulointerstitial fibrosis is the key pathological feature in chronic kidney diseases (CKDs) with no satisfactory therapies in clinic. Cilomilast is a second-generation, selective phosphodiesterase-4 inhibitor, but its role in renal tubulointerstitial fibrosis in CKD remains uncle...

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Detalles Bibliográficos
Autores principales:	Xu, Man, Li, Shumin, Wang, Jiajia, Huang, Songming, Zhang, Aihua, Zhang, Yue, Gu, Wei, Yu, Xiaowen, Jia, Zhanjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859332/ https://www.ncbi.nlm.nih.gov/pubmed/33553218 http://dx.doi.org/10.3389/fmed.2020.626140

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