Cargando…

Data-driven identification of ageing-related diseases from electronic health records

Reducing the burden of late-life morbidity requires an understanding of the mechanisms of ageing-related diseases (ARDs), defined as diseases that accumulate with increasing age. This has been hampered by the lack of formal criteria to identify ARDs. Here, we present a framework to identify ARDs usi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kuan, Valerie, Fraser, Helen C., Hingorani, Melanie, Denaxas, Spiros, Gonzalez-Izquierdo, Arturo, Direk, Kenan, Nitsch, Dorothea, Mathur, Rohini, Parisinos, Constantinos A., Lumbers, R. Thomas, Sofat, Reecha, Wong, Ian C. K., Casas, Juan P., Thornton, Janet M., Hemingway, Harry, Partridge, Linda, Hingorani, Aroon D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859412/ https://www.ncbi.nlm.nih.gov/pubmed/33536532 http://dx.doi.org/10.1038/s41598-021-82459-y

Ejemplares similares

A chronological map of 308 physical and mental health conditions from 4 million individuals in the English National Health Service
por: Kuan, Valerie, et al.
Publicado: (2019)

Improving the odds of drug development success through human genomics: modelling study
por: Hingorani, Aroon D., et al.
Publicado: (2019)

Low eosinophil and low lymphocyte counts and the incidence of 12 cardiovascular diseases: a CALIBER cohort study
por: Shah, Anoop Dinesh, et al.
Publicado: (2016)

Neutrophil Counts and Initial Presentation of 12 Cardiovascular Diseases: A CALIBER Cohort Study
por: Shah, Anoop Dinesh, et al.
Publicado: (2017)

UK phenomics platform for developing and validating electronic health record phenotypes: CALIBER
por: Denaxas, Spiros, et al.
Publicado: (2019)

Variation in Interleukin 6 Receptor Gene Associates With Risk of Crohn’s Disease and Ulcerative Colitis
por: Parisinos, Constantinos A., et al.
Publicado: (2018)

Association of Smoking, Alcohol Consumption, Blood Pressure, Body Mass Index, and Glycemic Risk Factors With Age-Related Macular Degeneration: A Mendelian Randomization Study
por: Kuan, Valerie, et al.
Publicado: (2021)

Translating genomics into improved healthcare
por: Hingorani, Aroon D, et al.
Publicado: (2010)

Methods for enhancing the reproducibility of biomedical research findings using electronic health records
por: Denaxas, Spiros, et al.
Publicado: (2017)

Performance of polygenic risk scores in screening, prediction, and risk stratification: secondary analysis of data in the Polygenic Score Catalog
por: Hingorani, Aroon D, et al.
Publicado: (2023)

Elevated plasma triglyceride concentration and risk of adverse clinical outcomes in 1.5 million people: a CALIBER linked electronic health record study
por: Patel, Riyaz S., et al.
Publicado: (2022)

Could NICE guidance on the choice of blood pressure lowering drugs be simplified?
por: Sofat, Reecha, et al.
Publicado: (2012)

Time spent at blood pressure target and the risk of death and cardiovascular diseases
por: Chung, Sheng-Chia, et al.
Publicado: (2018)

Data Resource Profile: Cardiovascular disease research using linked bespoke studies and electronic health records (CALIBER)
por: Denaxas, Spiros C, et al.
Publicado: (2012)

Reproducible disease phenotyping at scale: Example of coronary artery disease in UK Biobank
por: Patel, Riyaz S., et al.
Publicado: (2022)

Prognostic models for stable coronary artery disease based on electronic health record cohort of 102 023 patients
por: Rapsomaniki, Eleni, et al.
Publicado: (2014)

Biological mechanisms of aging predict age‐related disease co‐occurrence in patients
por: Fraser, Helen C., et al.
Publicado: (2022)

Circulating Apolipoprotein E Concentration and Cardiovascular Disease Risk: Meta-analysis of Results from Three Studies
por: Sofat, Reecha, et al.
Publicado: (2016)

Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis
por: Parisinos, Constantinos A., et al.
Publicado: (2020)

Corrigendum to: “Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis” [J Hepatol (2020) 241-251]
por: Parisinos, Constantinos A., et al.
Publicado: (2020)

An informatics consult approach for generating clinical evidence for treatment decisions
por: Lai, Alvina G., et al.
Publicado: (2021)

Selecting instruments for Mendelian randomization in the wake of genome-wide association studies
por: Swerdlow, Daniel I, et al.
Publicado: (2016)

Emergency department attendance after telephone triage
por: Denaxas, Spiros, et al.
Publicado: (2017)

Polygenic risk scores for coronary artery disease and subsequent event risk amongst established cases
por: Howe, Laurence J, et al.
Publicado: (2020)

Weight Change and the Onset of Cardiovascular Diseases: Emulating Trials Using Electronic Health Records
por: Katsoulis, Michail, et al.
Publicado: (2021)

Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people
por: Rapsomaniki, Eleni, et al.
Publicado: (2014)

Translating and evaluating historic phenotyping algorithms using SNOMED CT
por: Elkheder, Musaab, et al.
Publicado: (2022)

A population‐based study of 92 clinically recognized risk factors for heart failure: co‐occurrence, prognosis and preventive potential
por: Banerjee, Amitava, et al.
Publicado: (2022)

Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration
por: Wilman, Henry R., et al.
Publicado: (2019)

Ethnicity and the first diagnosis of a wide range of cardiovascular diseases: Associations in a linked electronic health record cohort of 1 million patients
por: George, Julie, et al.
Publicado: (2017)

Probability of encountering Covid-19 patients based on prevalence and testing during resumption of ophthalmology services
por: Keller, Johannes, et al.
Publicado: (2020)

Transforming and evaluating electronic health record disease phenotyping algorithms using the OMOP common data model: a case study in heart failure
por: Papez, Vaclav, et al.
Publicado: (2021)

Risk factors for incident heart failure in age‐ and sex‐specific strata: a population‐based cohort using linked electronic health records
por: Uijl, Alicia, et al.
Publicado: (2019)

Development and validation of a prediction model to estimate the risk of liver cirrhosis in primary care patients with abnormal liver blood test results: protocol for an electronic health record study in Clinical Practice Research Datalink
por: Härmälä, Suvi, et al.
Publicado: (2019)

C-Reactive Protein and Prognosis in Diabetes: Getting to the Heart of the Matter
por: Sattar, Naveed, et al.
Publicado: (2009)

Bleeding in cardiac patients prescribed antithrombotic drugs: electronic health record phenotyping algorithms, incidence, trends and prognosis
por: Pasea, Laura, et al.
Publicado: (2019)

Low-density lipoprotein cholesterol and atrial fibrillation; A Mendelian randomization study using UK-Biobank data
por: Katsoulis, Michail, et al.
Publicado: (2017)

Clopidogrel and interaction with proton pump inhibitors: comparison between cohort and within person study designs
por: Douglas, Ian J, et al.
Publicado: (2012)

The Genetics of Primary Haemorrhagic Stroke, Subarachnoid Haemorrhage and Ruptured Intracranial Aneurysms in Adults
por: Peck, George, et al.
Publicado: (2008)

Threshold Haemoglobin Levels and the Prognosis of Stable Coronary Disease: Two New Cohorts and a Systematic Review and Meta-Analysis
por: Shah, Anoop D., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_s8ibcdee61f750i6aopj3lmok8