Instability of sputum molecular phenotypes in U-BIOPRED severe asthma

At 1 year, 45% of severe asthma change molecular phenotype as determined by sputum transcriptomic analysis. Together with concomitant shift in sputum granulocytic markers, this may indicate variability of driving mechanisms in this unstable group. https://bit.ly/35aj489

Detalles Bibliográficos
Autores principales: Kermani, Nazanin Z., Pavlidis, Stelios, Xie, Jiaxing, Sun, Kai, Loza, Matthew, Baribaud, Fred, Fowler, Steve J., Shaw, Dominic E., Fleming, Louise J., Howarth, Peter H., Sousa, Ana R., Corfield, Julie, Auffray, Charles, De Meulder, Bertrand, Sterk, Peter J., Guo, Yike, Uddin, Mohib, Djukanovic, Ratko, Adcock, Ian M., Chung, Kian Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2021
Materias:
Agora
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859503/
https://www.ncbi.nlm.nih.gov/pubmed/33008937
http://dx.doi.org/10.1183/13993003.01836-2020
Descripción
Sumario:At 1 year, 45% of severe asthma change molecular phenotype as determined by sputum transcriptomic analysis. Together with concomitant shift in sputum granulocytic markers, this may indicate variability of driving mechanisms in this unstable group. https://bit.ly/35aj489

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