Notch signaling: Its essential roles in bone and craniofacial development

Notch is a cell–cell signaling pathway that is involved in a host of activities including development, oncogenesis, skeletal homeostasis, and much more. More specifically, recent research has demonstrated the importance of Notch signaling in osteogenic differentiation, bone healing, and in the devel...

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Detalles Bibliográficos
Autores principales: Pakvasa, Mikhail, Haravu, Pranav, Boachie-Mensah, Michael, Jones, Alonzo, Coalson, Elam, Liao, Junyi, Zeng, Zongyue, Wu, Di, Qin, Kevin, Wu, Xiaoxing, Luo, Huaxiu, Zhang, Jing, Zhang, Meng, He, Fang, Mao, Yukun, Zhang, Yongtao, Niu, Changchun, Wu, Meng, Zhao, Xia, Wang, Hao, Huang, Linjuan, Shi, Deyao, Liu, Qing, Ni, Na, Fu, Kai, Lee, Michael J., Wolf, Jennifer Moriatis, Athiviraham, Aravind, Ho, Sherwin S., He, Tong-Chuan, Hynes, Kelly, Strelzow, Jason, El Dafrawy, Mostafa, Reid, Russell R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859553/
https://www.ncbi.nlm.nih.gov/pubmed/33569510
http://dx.doi.org/10.1016/j.gendis.2020.04.006
Descripción
Sumario:Notch is a cell–cell signaling pathway that is involved in a host of activities including development, oncogenesis, skeletal homeostasis, and much more. More specifically, recent research has demonstrated the importance of Notch signaling in osteogenic differentiation, bone healing, and in the development of the skeleton. The craniofacial skeleton is complex and understanding its development has remained an important focus in biology. In this review we briefly summarize what recent research has revealed about Notch signaling and the current understanding of how the skeleton, skull, and face develop. We then discuss the crucial role that Notch plays in both craniofacial development and the skeletal system, and what importance it may play in the future.

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