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Network Analysis of Common Genes and Transcriptional Factors between Celiac Disease and Inflammatory Bowel Diseases

BACKGROUND Understanding the associations among different disorders remarkably improves their diagnosis and treatments. Celiac disease is the most complicated and prevalent form of immune-mediated diseases. On the other hand, inflammatory bowel diseases lead to inflammation of the intestine with an...

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Autores principales: Izadi, Fereshteh, Soheilifar, Mohammad Hasan, Keshmiri Neghab, Hoda, Soheilifar, Mahya, Esmaeeli Djavid, Gholamreza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Association of Gastroerterology and Hepatology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859603/
https://www.ncbi.nlm.nih.gov/pubmed/33564383
http://dx.doi.org/10.34172/mejdd.2020.191
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author Izadi, Fereshteh
Soheilifar, Mohammad Hasan
Keshmiri Neghab, Hoda
Soheilifar, Mahya
Esmaeeli Djavid, Gholamreza
author_facet Izadi, Fereshteh
Soheilifar, Mohammad Hasan
Keshmiri Neghab, Hoda
Soheilifar, Mahya
Esmaeeli Djavid, Gholamreza
author_sort Izadi, Fereshteh
collection PubMed
description BACKGROUND Understanding the associations among different disorders remarkably improves their diagnosis and treatments. Celiac disease is the most complicated and prevalent form of immune-mediated diseases. On the other hand, inflammatory bowel diseases lead to inflammation of the intestine with an unknown cause. Although inflammatory bowel diseases have been often thought of as an autoimmune disorder, they can be triggered by whatever that can lead to the inflammation in the whole bowel. Henceforth, both aforementioned diseases are related to autoimmune attacks and cause a sort of inflammatory event, which exploring trade-off among them supposedly will lead to discovering important genes and, in turn, to the possible common therapeutic protocols. In the current study, we aimed to determine the correlation between the common genes in celiac disease and inflammatory bowel diseases. METHODS 314 and 851 genes correlated with celiac disease and inflammatory bowel diseases respectively extracted from DisGeNET were subjected to an in-silico data analysis framework to mine prognosticates genes and the associated pathways. RESULTS 149 shared genes between these diseases regulated by highlighted transcription factors NFKB1, IRF1, STAT1, HSF1, GATA3 were characterized as discriminating molecules, which by further screening were enriched in pathways mostly involved in apoptosis, T cell activation, and cytokine, chemokine, and interleukin signaling. CONCLUSION We observed that the identified common genes were associated with a wide range of pathogenic mechanisms underlying these diseases.
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spelling pubmed-78596032021-02-08 Network Analysis of Common Genes and Transcriptional Factors between Celiac Disease and Inflammatory Bowel Diseases Izadi, Fereshteh Soheilifar, Mohammad Hasan Keshmiri Neghab, Hoda Soheilifar, Mahya Esmaeeli Djavid, Gholamreza Middle East J Dig Dis Original Article BACKGROUND Understanding the associations among different disorders remarkably improves their diagnosis and treatments. Celiac disease is the most complicated and prevalent form of immune-mediated diseases. On the other hand, inflammatory bowel diseases lead to inflammation of the intestine with an unknown cause. Although inflammatory bowel diseases have been often thought of as an autoimmune disorder, they can be triggered by whatever that can lead to the inflammation in the whole bowel. Henceforth, both aforementioned diseases are related to autoimmune attacks and cause a sort of inflammatory event, which exploring trade-off among them supposedly will lead to discovering important genes and, in turn, to the possible common therapeutic protocols. In the current study, we aimed to determine the correlation between the common genes in celiac disease and inflammatory bowel diseases. METHODS 314 and 851 genes correlated with celiac disease and inflammatory bowel diseases respectively extracted from DisGeNET were subjected to an in-silico data analysis framework to mine prognosticates genes and the associated pathways. RESULTS 149 shared genes between these diseases regulated by highlighted transcription factors NFKB1, IRF1, STAT1, HSF1, GATA3 were characterized as discriminating molecules, which by further screening were enriched in pathways mostly involved in apoptosis, T cell activation, and cytokine, chemokine, and interleukin signaling. CONCLUSION We observed that the identified common genes were associated with a wide range of pathogenic mechanisms underlying these diseases. Iranian Association of Gastroerterology and Hepatology 2020-10 /pmc/articles/PMC7859603/ /pubmed/33564383 http://dx.doi.org/10.34172/mejdd.2020.191 Text en © 2020 Middle East Journal of Digestive Diseases This work is published by Middle East Journal of Digestive Diseaes as an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Original Article
Izadi, Fereshteh
Soheilifar, Mohammad Hasan
Keshmiri Neghab, Hoda
Soheilifar, Mahya
Esmaeeli Djavid, Gholamreza
Network Analysis of Common Genes and Transcriptional Factors between Celiac Disease and Inflammatory Bowel Diseases
title Network Analysis of Common Genes and Transcriptional Factors between Celiac Disease and Inflammatory Bowel Diseases
title_full Network Analysis of Common Genes and Transcriptional Factors between Celiac Disease and Inflammatory Bowel Diseases
title_fullStr Network Analysis of Common Genes and Transcriptional Factors between Celiac Disease and Inflammatory Bowel Diseases
title_full_unstemmed Network Analysis of Common Genes and Transcriptional Factors between Celiac Disease and Inflammatory Bowel Diseases
title_short Network Analysis of Common Genes and Transcriptional Factors between Celiac Disease and Inflammatory Bowel Diseases
title_sort network analysis of common genes and transcriptional factors between celiac disease and inflammatory bowel diseases
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859603/
https://www.ncbi.nlm.nih.gov/pubmed/33564383
http://dx.doi.org/10.34172/mejdd.2020.191
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