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Case Report: The Coronavirus Disease 2019 (COVID-19) Pneumonia With Multiple Thromboembolism

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) broke out in Wuhan, China, in late December 2019 and has since spread rapidly around the world. Severe coronavirus disease 2019 (COVID-19) pneumonia patients have abnormal blood coagulation function, but their thromboembolism prevalence is...

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Autores principales: Cao, Tingting, Zhang, Guqin, Xie, Huabing, Pellegrini, Emily, Li, Jin, Chen, Xiaoxing, Pan, Huaqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859614/
https://www.ncbi.nlm.nih.gov/pubmed/33551979
http://dx.doi.org/10.3389/fneur.2020.625272
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author Cao, Tingting
Zhang, Guqin
Xie, Huabing
Pellegrini, Emily
Li, Jin
Chen, Xiaoxing
Pan, Huaqin
author_facet Cao, Tingting
Zhang, Guqin
Xie, Huabing
Pellegrini, Emily
Li, Jin
Chen, Xiaoxing
Pan, Huaqin
author_sort Cao, Tingting
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) broke out in Wuhan, China, in late December 2019 and has since spread rapidly around the world. Severe coronavirus disease 2019 (COVID-19) pneumonia patients have abnormal blood coagulation function, but their thromboembolism prevalence is still unknown. We reported a case of a 49-year-old man infected with COVID-19, presenting with fever, chest pain, limb weakness, myalgia, and dyspnea. The patient was diagnosed with severe COVID-19 pneumonia, pulmonary thromboembolism (PTE), deep vein thrombosis (DVT), and cerebral infarction. He received supportive and empirical treatment including anticoagulant treatment, anti-inflammatory treatment, oxygen supply, and inhalation therapy. The patient's symptoms, CT images, and laboratory results improved after treatment, and a throat swab was reported to be negative for SARS-CoV-2 virus by polymerase chain reaction (PCR) test. However, on day 51 of illness onset, CT reexamination demonstrated hemorrhagic infarction. Anticoagulant therapy was discontinued temporarily. After the patient tested negative for SARS-CoV-2 virus by PCR test six more times, he was discharged and remained in home quarantine. This case highlights the importance of clinician attentiveness to the appearance of multiple thromboembolism, especially in patients with severe pulmonary damage. It also emphasizes the diagnostic value of early CT imaging and the need for effective treatment once thrombotic events occur.
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spelling pubmed-78596142021-02-05 Case Report: The Coronavirus Disease 2019 (COVID-19) Pneumonia With Multiple Thromboembolism Cao, Tingting Zhang, Guqin Xie, Huabing Pellegrini, Emily Li, Jin Chen, Xiaoxing Pan, Huaqin Front Neurol Neurology Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) broke out in Wuhan, China, in late December 2019 and has since spread rapidly around the world. Severe coronavirus disease 2019 (COVID-19) pneumonia patients have abnormal blood coagulation function, but their thromboembolism prevalence is still unknown. We reported a case of a 49-year-old man infected with COVID-19, presenting with fever, chest pain, limb weakness, myalgia, and dyspnea. The patient was diagnosed with severe COVID-19 pneumonia, pulmonary thromboembolism (PTE), deep vein thrombosis (DVT), and cerebral infarction. He received supportive and empirical treatment including anticoagulant treatment, anti-inflammatory treatment, oxygen supply, and inhalation therapy. The patient's symptoms, CT images, and laboratory results improved after treatment, and a throat swab was reported to be negative for SARS-CoV-2 virus by polymerase chain reaction (PCR) test. However, on day 51 of illness onset, CT reexamination demonstrated hemorrhagic infarction. Anticoagulant therapy was discontinued temporarily. After the patient tested negative for SARS-CoV-2 virus by PCR test six more times, he was discharged and remained in home quarantine. This case highlights the importance of clinician attentiveness to the appearance of multiple thromboembolism, especially in patients with severe pulmonary damage. It also emphasizes the diagnostic value of early CT imaging and the need for effective treatment once thrombotic events occur. Frontiers Media S.A. 2021-01-12 /pmc/articles/PMC7859614/ /pubmed/33551979 http://dx.doi.org/10.3389/fneur.2020.625272 Text en Copyright © 2021 Cao, Zhang, Xie, Pellegrini, Li, Chen and Pan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Cao, Tingting
Zhang, Guqin
Xie, Huabing
Pellegrini, Emily
Li, Jin
Chen, Xiaoxing
Pan, Huaqin
Case Report: The Coronavirus Disease 2019 (COVID-19) Pneumonia With Multiple Thromboembolism
title Case Report: The Coronavirus Disease 2019 (COVID-19) Pneumonia With Multiple Thromboembolism
title_full Case Report: The Coronavirus Disease 2019 (COVID-19) Pneumonia With Multiple Thromboembolism
title_fullStr Case Report: The Coronavirus Disease 2019 (COVID-19) Pneumonia With Multiple Thromboembolism
title_full_unstemmed Case Report: The Coronavirus Disease 2019 (COVID-19) Pneumonia With Multiple Thromboembolism
title_short Case Report: The Coronavirus Disease 2019 (COVID-19) Pneumonia With Multiple Thromboembolism
title_sort case report: the coronavirus disease 2019 (covid-19) pneumonia with multiple thromboembolism
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859614/
https://www.ncbi.nlm.nih.gov/pubmed/33551979
http://dx.doi.org/10.3389/fneur.2020.625272
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