A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs

A combination of vaccination approaches will likely be necessary to fully control the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Here, we show that modified vaccinia Ankara (MVA) vectors expressing membrane-anchored pre-fusion stabilized spike (MVA/S) but not secreted S1...

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Detalles Bibliográficos
Autores principales: Routhu, Nanda Kishore, Cheedarla, Narayanaiah, Gangadhara, Sailaja, Bollimpelli, Venkata Satish, Boddapati, Arun K., Shiferaw, Ayalnesh, Rahman, Sheikh Abdul, Sahoo, Anusmita, Edara, Venkata Viswanadh, Lai, Lilin, Floyd, Katharine, Wang, Shelly, Fischinger, Stephanie, Atyeo, Caroline, Shin, Sally A., Gumber, Sanjeev, Kirejczyk, Shannon, Cohen, Joyce, Jean, Sherrie M., Wood, Jennifer S., Connor-Stroud, Fawn, Stammen, Rachelle L., Upadhyay, Amit A., Pellegrini, Kathryn, Montefiori, David, Shi, Pei-Yong, Menachery, Vineet D., Alter, Galit, Vanderford, Thomas H., Bosinger, Steven E., Suthar, Mehul S., Amara, Rama Rao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859620/
https://www.ncbi.nlm.nih.gov/pubmed/33631118
http://dx.doi.org/10.1016/j.immuni.2021.02.001

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