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sym-2 loss-of-function causes glutamatergic neurodegeneration after oxidative stress
Although some RNA-binding proteins are known to contribute to neurodegeneration, the genetic interaction between the genes encoding these proteins is unclear. Here, we examine the interaction between sym-2, the gene encoding an ortholog of hnRNPF and hnRNPH, and hrpa-1, the ortholog of of the gene e...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Caltech Library
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859837/ https://www.ncbi.nlm.nih.gov/pubmed/33554054 http://dx.doi.org/10.17912/micropub.biology.000363 |
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author | Ryan, Veronica H. Hart, Anne C. |
author_facet | Ryan, Veronica H. Hart, Anne C. |
author_sort | Ryan, Veronica H. |
collection | PubMed |
description | Although some RNA-binding proteins are known to contribute to neurodegeneration, the genetic interaction between the genes encoding these proteins is unclear. Here, we examine the interaction between sym-2, the gene encoding an ortholog of hnRNPF and hnRNPH, and hrpa-1, the ortholog of of the gene encoding hnRNPA2, which when mutated causes multisystem proteinopathy. We find that after 22 hours, but not 4 hours, of paraquat-induced oxidative stress, sym-2(mn617) has a mild glutamatergic neurodegeneration phenotype. Interestingly, this defect is rescued by expression of chimeric WT hrpa-1, but not mutant. Thus, we identify a curious genetic interaction between sym-2 and hrpa-1. |
format | Online Article Text |
id | pubmed-7859837 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Caltech Library |
record_format | MEDLINE/PubMed |
spelling | pubmed-78598372021-02-05 sym-2 loss-of-function causes glutamatergic neurodegeneration after oxidative stress Ryan, Veronica H. Hart, Anne C. MicroPubl Biol New Finding Although some RNA-binding proteins are known to contribute to neurodegeneration, the genetic interaction between the genes encoding these proteins is unclear. Here, we examine the interaction between sym-2, the gene encoding an ortholog of hnRNPF and hnRNPH, and hrpa-1, the ortholog of of the gene encoding hnRNPA2, which when mutated causes multisystem proteinopathy. We find that after 22 hours, but not 4 hours, of paraquat-induced oxidative stress, sym-2(mn617) has a mild glutamatergic neurodegeneration phenotype. Interestingly, this defect is rescued by expression of chimeric WT hrpa-1, but not mutant. Thus, we identify a curious genetic interaction between sym-2 and hrpa-1. Caltech Library 2021-02-03 /pmc/articles/PMC7859837/ /pubmed/33554054 http://dx.doi.org/10.17912/micropub.biology.000363 Text en Copyright: © 2021 by the authors https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | New Finding Ryan, Veronica H. Hart, Anne C. sym-2 loss-of-function causes glutamatergic neurodegeneration after oxidative stress |
title | sym-2 loss-of-function causes glutamatergic neurodegeneration after oxidative stress |
title_full | sym-2 loss-of-function causes glutamatergic neurodegeneration after oxidative stress |
title_fullStr | sym-2 loss-of-function causes glutamatergic neurodegeneration after oxidative stress |
title_full_unstemmed | sym-2 loss-of-function causes glutamatergic neurodegeneration after oxidative stress |
title_short | sym-2 loss-of-function causes glutamatergic neurodegeneration after oxidative stress |
title_sort | sym-2 loss-of-function causes glutamatergic neurodegeneration after oxidative stress |
topic | New Finding |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859837/ https://www.ncbi.nlm.nih.gov/pubmed/33554054 http://dx.doi.org/10.17912/micropub.biology.000363 |
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