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Mutation in the distal NPxY motif of LRP1 alleviates dietary cholesterol-induced dyslipidemia and tissue inflammation

The impairment of LDL receptor-related protein-1 (LRP1) in numerous cell types is associated with obesity, diabetes, and fatty liver disease. Here, we compared the metabolic phenotype of C57BL/6J wild-type and LRP1 knock-in mice carrying an inactivating mutation in the distal NPxY motif after feedin...

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Detalles Bibliográficos
Autores principales:	Jaeschke, Anja, Haller, April, Cash, James G., Nam, Christopher, Igel, Emily, Roebroek, Anton J.M., Hui, David Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859857/ https://www.ncbi.nlm.nih.gov/pubmed/33500241 http://dx.doi.org/10.1194/jlr.RA120001141

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