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Ethanolamine Plasmalogen Suppresses Apoptosis in Human Intestinal Tract Cells in Vitro by Attenuating Induced Inflammatory Stress
[Image: see text] Ethanolamine plasmalogen (PlsEtn) is a subtype of ethanolamine glycerophospholipids (EtnGpl). Recently, PlsEtn has attracted increasing research interest due to its beneficial effects in health and disease; however, its functional role in colonic health has not been well establishe...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7860056/ https://www.ncbi.nlm.nih.gov/pubmed/33553930 http://dx.doi.org/10.1021/acsomega.0c05545 |
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author | Nguma, Ephantus Yamashita, Shinji Kumagai, Kei Otoki, Yurika Yamamoto, Ayaka Eitsuka, Takahiro Nakagawa, Kiyotaka Miyazawa, Teruo Kinoshita, Mikio |
author_facet | Nguma, Ephantus Yamashita, Shinji Kumagai, Kei Otoki, Yurika Yamamoto, Ayaka Eitsuka, Takahiro Nakagawa, Kiyotaka Miyazawa, Teruo Kinoshita, Mikio |
author_sort | Nguma, Ephantus |
collection | PubMed |
description | [Image: see text] Ethanolamine plasmalogen (PlsEtn) is a subtype of ethanolamine glycerophospholipids (EtnGpl). Recently, PlsEtn has attracted increasing research interest due to its beneficial effects in health and disease; however, its functional role in colonic health has not been well established. This study was conducted to determine the mechanism underlying the antiapoptotic effect of PlsEtn in human intestinal tract cells under induced inflammatory stress. Lipopolysaccharide induced apoptosis of differentiated Caco-2 cells, which was suppressed by EtnGpl in a dose-dependent manner. Cells treated with ascidian muscle EtnGpl containing high levels of PlsEtn demonstrated a lower degree of apoptosis, and downregulated TNF-α and apoptosis-related proteins compared to those treated with porcine liver EtnGpl containing low PlsEtn. This indicates that PlsEtn exerted the observed effects, which provided protection against induced inflammatory stress. Overall, our results suggest that PlsEtn with abundant vinyl ether linkages is potentially beneficial in preventing the initiation of inflammatory bowel disease and colon cancer. |
format | Online Article Text |
id | pubmed-7860056 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-78600562021-02-05 Ethanolamine Plasmalogen Suppresses Apoptosis in Human Intestinal Tract Cells in Vitro by Attenuating Induced Inflammatory Stress Nguma, Ephantus Yamashita, Shinji Kumagai, Kei Otoki, Yurika Yamamoto, Ayaka Eitsuka, Takahiro Nakagawa, Kiyotaka Miyazawa, Teruo Kinoshita, Mikio ACS Omega [Image: see text] Ethanolamine plasmalogen (PlsEtn) is a subtype of ethanolamine glycerophospholipids (EtnGpl). Recently, PlsEtn has attracted increasing research interest due to its beneficial effects in health and disease; however, its functional role in colonic health has not been well established. This study was conducted to determine the mechanism underlying the antiapoptotic effect of PlsEtn in human intestinal tract cells under induced inflammatory stress. Lipopolysaccharide induced apoptosis of differentiated Caco-2 cells, which was suppressed by EtnGpl in a dose-dependent manner. Cells treated with ascidian muscle EtnGpl containing high levels of PlsEtn demonstrated a lower degree of apoptosis, and downregulated TNF-α and apoptosis-related proteins compared to those treated with porcine liver EtnGpl containing low PlsEtn. This indicates that PlsEtn exerted the observed effects, which provided protection against induced inflammatory stress. Overall, our results suggest that PlsEtn with abundant vinyl ether linkages is potentially beneficial in preventing the initiation of inflammatory bowel disease and colon cancer. American Chemical Society 2021-01-22 /pmc/articles/PMC7860056/ /pubmed/33553930 http://dx.doi.org/10.1021/acsomega.0c05545 Text en © 2021 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited. |
spellingShingle | Nguma, Ephantus Yamashita, Shinji Kumagai, Kei Otoki, Yurika Yamamoto, Ayaka Eitsuka, Takahiro Nakagawa, Kiyotaka Miyazawa, Teruo Kinoshita, Mikio Ethanolamine Plasmalogen Suppresses Apoptosis in Human Intestinal Tract Cells in Vitro by Attenuating Induced Inflammatory Stress |
title | Ethanolamine Plasmalogen Suppresses Apoptosis in Human
Intestinal Tract Cells in Vitro by Attenuating Induced
Inflammatory Stress |
title_full | Ethanolamine Plasmalogen Suppresses Apoptosis in Human
Intestinal Tract Cells in Vitro by Attenuating Induced
Inflammatory Stress |
title_fullStr | Ethanolamine Plasmalogen Suppresses Apoptosis in Human
Intestinal Tract Cells in Vitro by Attenuating Induced
Inflammatory Stress |
title_full_unstemmed | Ethanolamine Plasmalogen Suppresses Apoptosis in Human
Intestinal Tract Cells in Vitro by Attenuating Induced
Inflammatory Stress |
title_short | Ethanolamine Plasmalogen Suppresses Apoptosis in Human
Intestinal Tract Cells in Vitro by Attenuating Induced
Inflammatory Stress |
title_sort | ethanolamine plasmalogen suppresses apoptosis in human
intestinal tract cells in vitro by attenuating induced
inflammatory stress |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7860056/ https://www.ncbi.nlm.nih.gov/pubmed/33553930 http://dx.doi.org/10.1021/acsomega.0c05545 |
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