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Mutational inactivation of Apc in the intestinal epithelia compromises cellular organisation

The adenomatous polyposis coli (Apc) protein regulates diverse effector pathways essential for tissue homeostasis. Truncating oncogenic mutations in Apc removing its Wnt pathway and microtubule regulatory domains drives intestinal epithelia tumorigenesis. Exuberant cell proliferation is one well-est...

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Detalles Bibliográficos
Autores principales:	Rannikmae, Helena, Peel, Samantha, Barry, Simon, Senda, Takao, de la Roche, Marc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7860127/ https://www.ncbi.nlm.nih.gov/pubmed/33335067 http://dx.doi.org/10.1242/jcs.250019

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