Water Solubilization and Thermal Stimuli-Triggered Release of Porphyrin Derivatives Using Thermoresponsive Polysaccharide Hydroxypropyl Cellulose for Mitochondria-Targeted Photodynamic Therapy

[Image: see text] With minimal invasiveness and spatiotemporal therapeutic effects, photodynamic therapy is one of the most elegant strategies for achieving effective tumor therapy. Herein, a facile preparation and thermal process-triggered release of water-soluble photosensitizer 5,10,15,20-tetraki...

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Autores principales: Kawasaki, Riku, Yamana, Keita, Shimada, Risako, Sugikawa, Kouta, Ikeda, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7860233/
https://www.ncbi.nlm.nih.gov/pubmed/33553937
http://dx.doi.org/10.1021/acsomega.0c05647
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author Kawasaki, Riku
Yamana, Keita
Shimada, Risako
Sugikawa, Kouta
Ikeda, Atsushi
author_facet Kawasaki, Riku
Yamana, Keita
Shimada, Risako
Sugikawa, Kouta
Ikeda, Atsushi
author_sort Kawasaki, Riku
collection PubMed
description [Image: see text] With minimal invasiveness and spatiotemporal therapeutic effects, photodynamic therapy is one of the most elegant strategies for achieving effective tumor therapy. Herein, a facile preparation and thermal process-triggered release of water-soluble photosensitizer 5,10,15,20-tetrakis(4-hydroxyphenyl)porphyrin (THPP) has been developed using a thermoresponsive polysaccharide, hydroxypropyl cellulose. Current systems using hydroxypropyl cellulose enable manipulation of the loading capacity of THPP into a polymer matrix and the size of the complex by varying the temperature of the solution in preparation. Furthermore, current systems have enabled the release of THPP using a heating process, mimicking the surrounding of mitochondria, and have resulted in THPP potency as a mitochondria-targeted photodynamic therapy.
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spelling pubmed-78602332021-02-05 Water Solubilization and Thermal Stimuli-Triggered Release of Porphyrin Derivatives Using Thermoresponsive Polysaccharide Hydroxypropyl Cellulose for Mitochondria-Targeted Photodynamic Therapy Kawasaki, Riku Yamana, Keita Shimada, Risako Sugikawa, Kouta Ikeda, Atsushi ACS Omega [Image: see text] With minimal invasiveness and spatiotemporal therapeutic effects, photodynamic therapy is one of the most elegant strategies for achieving effective tumor therapy. Herein, a facile preparation and thermal process-triggered release of water-soluble photosensitizer 5,10,15,20-tetrakis(4-hydroxyphenyl)porphyrin (THPP) has been developed using a thermoresponsive polysaccharide, hydroxypropyl cellulose. Current systems using hydroxypropyl cellulose enable manipulation of the loading capacity of THPP into a polymer matrix and the size of the complex by varying the temperature of the solution in preparation. Furthermore, current systems have enabled the release of THPP using a heating process, mimicking the surrounding of mitochondria, and have resulted in THPP potency as a mitochondria-targeted photodynamic therapy. American Chemical Society 2021-01-19 /pmc/articles/PMC7860233/ /pubmed/33553937 http://dx.doi.org/10.1021/acsomega.0c05647 Text en © 2021 The Authors. Published by American Chemical Society This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License (http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html) , which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.
spellingShingle Kawasaki, Riku
Yamana, Keita
Shimada, Risako
Sugikawa, Kouta
Ikeda, Atsushi
Water Solubilization and Thermal Stimuli-Triggered Release of Porphyrin Derivatives Using Thermoresponsive Polysaccharide Hydroxypropyl Cellulose for Mitochondria-Targeted Photodynamic Therapy
title Water Solubilization and Thermal Stimuli-Triggered Release of Porphyrin Derivatives Using Thermoresponsive Polysaccharide Hydroxypropyl Cellulose for Mitochondria-Targeted Photodynamic Therapy
title_full Water Solubilization and Thermal Stimuli-Triggered Release of Porphyrin Derivatives Using Thermoresponsive Polysaccharide Hydroxypropyl Cellulose for Mitochondria-Targeted Photodynamic Therapy
title_fullStr Water Solubilization and Thermal Stimuli-Triggered Release of Porphyrin Derivatives Using Thermoresponsive Polysaccharide Hydroxypropyl Cellulose for Mitochondria-Targeted Photodynamic Therapy
title_full_unstemmed Water Solubilization and Thermal Stimuli-Triggered Release of Porphyrin Derivatives Using Thermoresponsive Polysaccharide Hydroxypropyl Cellulose for Mitochondria-Targeted Photodynamic Therapy
title_short Water Solubilization and Thermal Stimuli-Triggered Release of Porphyrin Derivatives Using Thermoresponsive Polysaccharide Hydroxypropyl Cellulose for Mitochondria-Targeted Photodynamic Therapy
title_sort water solubilization and thermal stimuli-triggered release of porphyrin derivatives using thermoresponsive polysaccharide hydroxypropyl cellulose for mitochondria-targeted photodynamic therapy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7860233/
https://www.ncbi.nlm.nih.gov/pubmed/33553937
http://dx.doi.org/10.1021/acsomega.0c05647
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