Preparation and Thermal Decomposition Kinetics of a New Type of a Magnetic Targeting Drug Carrier

[Image: see text] We have designed a new magnetic targeting drug carrier Fe(3)O(4)-PVA with a core of triiron tetroxide (Fe(3)O(4)) and a shell made of polyvinyl alcohol (PVA) to improve the hydrophilicity of Fe(3)O(4). With adriamycin hydrochloride as a model drug, this study goes on to measure the...

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Autores principales: Shi, Zhen, Wang, Yazhen, Xiao, Tianyuan, Dong, Shaobo, Lan, Tianyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7860512/
https://www.ncbi.nlm.nih.gov/pubmed/33553961
http://dx.doi.org/10.1021/acsomega.0c06075
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author Shi, Zhen
Wang, Yazhen
Xiao, Tianyuan
Dong, Shaobo
Lan, Tianyu
author_facet Shi, Zhen
Wang, Yazhen
Xiao, Tianyuan
Dong, Shaobo
Lan, Tianyu
author_sort Shi, Zhen
collection PubMed
description [Image: see text] We have designed a new magnetic targeting drug carrier Fe(3)O(4)-PVA with a core of triiron tetroxide (Fe(3)O(4)) and a shell made of polyvinyl alcohol (PVA) to improve the hydrophilicity of Fe(3)O(4). With adriamycin hydrochloride as a model drug, this study goes on to measure the drug carrier performance of Fe(3)O(4)-PVA. In addition, the thermal stability and enthalpy of thermal decomposition of Fe(3)O(4)-PVA were measured using a differential scanning calorimeter with a non-isothermal decomposition method. The kinetics of thermal decomposition of Fe(3)O(4)-PVA were also investigated. Over the course of this study, it was determined that the resulting drug carrier Fe(3)O(4)-PVA exhibited high drug loading levels and excellent release levels.
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spelling pubmed-78605122021-02-05 Preparation and Thermal Decomposition Kinetics of a New Type of a Magnetic Targeting Drug Carrier Shi, Zhen Wang, Yazhen Xiao, Tianyuan Dong, Shaobo Lan, Tianyu ACS Omega [Image: see text] We have designed a new magnetic targeting drug carrier Fe(3)O(4)-PVA with a core of triiron tetroxide (Fe(3)O(4)) and a shell made of polyvinyl alcohol (PVA) to improve the hydrophilicity of Fe(3)O(4). With adriamycin hydrochloride as a model drug, this study goes on to measure the drug carrier performance of Fe(3)O(4)-PVA. In addition, the thermal stability and enthalpy of thermal decomposition of Fe(3)O(4)-PVA were measured using a differential scanning calorimeter with a non-isothermal decomposition method. The kinetics of thermal decomposition of Fe(3)O(4)-PVA were also investigated. Over the course of this study, it was determined that the resulting drug carrier Fe(3)O(4)-PVA exhibited high drug loading levels and excellent release levels. American Chemical Society 2021-01-22 /pmc/articles/PMC7860512/ /pubmed/33553961 http://dx.doi.org/10.1021/acsomega.0c06075 Text en © 2021 The Authors. Published by American Chemical Society This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License (http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html) , which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.
spellingShingle Shi, Zhen
Wang, Yazhen
Xiao, Tianyuan
Dong, Shaobo
Lan, Tianyu
Preparation and Thermal Decomposition Kinetics of a New Type of a Magnetic Targeting Drug Carrier
title Preparation and Thermal Decomposition Kinetics of a New Type of a Magnetic Targeting Drug Carrier
title_full Preparation and Thermal Decomposition Kinetics of a New Type of a Magnetic Targeting Drug Carrier
title_fullStr Preparation and Thermal Decomposition Kinetics of a New Type of a Magnetic Targeting Drug Carrier
title_full_unstemmed Preparation and Thermal Decomposition Kinetics of a New Type of a Magnetic Targeting Drug Carrier
title_short Preparation and Thermal Decomposition Kinetics of a New Type of a Magnetic Targeting Drug Carrier
title_sort preparation and thermal decomposition kinetics of a new type of a magnetic targeting drug carrier
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7860512/
https://www.ncbi.nlm.nih.gov/pubmed/33553961
http://dx.doi.org/10.1021/acsomega.0c06075
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AT dongshaobo preparationandthermaldecompositionkineticsofanewtypeofamagnetictargetingdrugcarrier
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