Separate signaling events control TCR downregulation and T cell activation in primary human T cells

INTRODUCTION: T‐cell antigen receptor (TCR) interaction with cognate peptide:MHC complexes trigger clustering of TCR:CD3 complexes and signal transduction. Triggered TCR:CD3 complexes are rapidly internalized and degraded in a process called ligand‐induced TCR downregulation. Classic studies in immo...

Descripción completa

Detalles Bibliográficos
Autores principales: van der Donk, Lieve E. H., Ates, Louis S., van der Spek, Jet, Tukker, Laura M., Geijtenbeek, Teunis B. H., van Heijst, Jeroen W. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7860602/
https://www.ncbi.nlm.nih.gov/pubmed/33350598
http://dx.doi.org/10.1002/iid3.383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7860602/
https://www.ncbi.nlm.nih.gov/pubmed/33350598
http://dx.doi.org/10.1002/iid3.383

Ejemplares similares