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The performance of the alarmin HMGB1 in pediatric diseases: From lab to clinic

INTRODUCTION: The ubiquitously expressed nonhistone nuclear protein high‐mobility group box protein 1 (HMGB1) has different functions related to posttranslational modifications and cellular localization. In the nucleus, HMGB1 modulates gene transcription, replication and DNA repair as well as determ...

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Autores principales: Li, Bo, Peng, Xin, Li, He, Chen, Fei, Chen, Yuxia, Zhang, Yingqian, Le, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7860603/
https://www.ncbi.nlm.nih.gov/pubmed/33140586
http://dx.doi.org/10.1002/iid3.370
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author Li, Bo
Peng, Xin
Li, He
Chen, Fei
Chen, Yuxia
Zhang, Yingqian
Le, Kai
author_facet Li, Bo
Peng, Xin
Li, He
Chen, Fei
Chen, Yuxia
Zhang, Yingqian
Le, Kai
author_sort Li, Bo
collection PubMed
description INTRODUCTION: The ubiquitously expressed nonhistone nuclear protein high‐mobility group box protein 1 (HMGB1) has different functions related to posttranslational modifications and cellular localization. In the nucleus, HMGB1 modulates gene transcription, replication and DNA repair as well as determines chromosomal architecture. When the post‐transcriptional modified HMGB1 is released into the extracellular space, it triggers several physiological and pathological responses and initiates innate immunity through interacting with its reciprocal receptors (i.e., TLR4/2 and RAGE). The effect of HMGB1‐mediated inflammatory activation on different systems has received increasing attention. HMGB1 is now considered to be an alarmin and participates in multiple inflammation‐related diseases. In addition, HMGB1 also affects the occurrence and progression of tumors. However, most studies involving HMGB1 have been focused on adults or mature animals. Due to differences in disease characteristics between children and adults, it is necessary to clarify the role of HMGB1 in pediatric diseases. METHODS AND RESULTS: Through systematic database retrieval, this review aimed to first elaborate the characteristics of HMGB1 under physiological and pathological conditions and then discuss the clinical significance of HMGB1 in the pediatric diseases according to different systems. CONCLUSIONS: HMGB1 plays an important role in a variety of pediatric diseases and may be used as a diagnostic biomarker and therapeutic target for new strategies for the prevention and treatment of pediatric diseases.
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spelling pubmed-78606032021-02-05 The performance of the alarmin HMGB1 in pediatric diseases: From lab to clinic Li, Bo Peng, Xin Li, He Chen, Fei Chen, Yuxia Zhang, Yingqian Le, Kai Immun Inflamm Dis Reviews INTRODUCTION: The ubiquitously expressed nonhistone nuclear protein high‐mobility group box protein 1 (HMGB1) has different functions related to posttranslational modifications and cellular localization. In the nucleus, HMGB1 modulates gene transcription, replication and DNA repair as well as determines chromosomal architecture. When the post‐transcriptional modified HMGB1 is released into the extracellular space, it triggers several physiological and pathological responses and initiates innate immunity through interacting with its reciprocal receptors (i.e., TLR4/2 and RAGE). The effect of HMGB1‐mediated inflammatory activation on different systems has received increasing attention. HMGB1 is now considered to be an alarmin and participates in multiple inflammation‐related diseases. In addition, HMGB1 also affects the occurrence and progression of tumors. However, most studies involving HMGB1 have been focused on adults or mature animals. Due to differences in disease characteristics between children and adults, it is necessary to clarify the role of HMGB1 in pediatric diseases. METHODS AND RESULTS: Through systematic database retrieval, this review aimed to first elaborate the characteristics of HMGB1 under physiological and pathological conditions and then discuss the clinical significance of HMGB1 in the pediatric diseases according to different systems. CONCLUSIONS: HMGB1 plays an important role in a variety of pediatric diseases and may be used as a diagnostic biomarker and therapeutic target for new strategies for the prevention and treatment of pediatric diseases. John Wiley and Sons Inc. 2020-11-02 /pmc/articles/PMC7860603/ /pubmed/33140586 http://dx.doi.org/10.1002/iid3.370 Text en © 2020 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Li, Bo
Peng, Xin
Li, He
Chen, Fei
Chen, Yuxia
Zhang, Yingqian
Le, Kai
The performance of the alarmin HMGB1 in pediatric diseases: From lab to clinic
title The performance of the alarmin HMGB1 in pediatric diseases: From lab to clinic
title_full The performance of the alarmin HMGB1 in pediatric diseases: From lab to clinic
title_fullStr The performance of the alarmin HMGB1 in pediatric diseases: From lab to clinic
title_full_unstemmed The performance of the alarmin HMGB1 in pediatric diseases: From lab to clinic
title_short The performance of the alarmin HMGB1 in pediatric diseases: From lab to clinic
title_sort performance of the alarmin hmgb1 in pediatric diseases: from lab to clinic
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7860603/
https://www.ncbi.nlm.nih.gov/pubmed/33140586
http://dx.doi.org/10.1002/iid3.370
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