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BDNF Val(66)Met polymorphism and resilience in major depressive disorder: the impact of cognitive psychotherapy

OBJECTIVE: Clinical and biological correlates of resilience in major depressive disorder are scarce. We aimed to investigate the effect of the Val(66)Met polymorphism in the BDNF gene on resilience scores in major depressive disorder patients and evaluate the polymorphism’s moderation effect on resi...

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Autores principales: Peters, Renata B., Xavier, Janaína, Mondin, Thaíse C., Cardoso, Taiane de A., Ferreira, Fabiana B., Teixeira, Liana, Gräeff, Kiane, Quevedo, Luciana de A., Jansen, Karen, Souza, Luciano D., Oses, Jean P., Pinheiro, Ricardo T., da Silva, Ricardo A., Ghisleni, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Psiquiatria 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861181/
https://www.ncbi.nlm.nih.gov/pubmed/32844885
http://dx.doi.org/10.1590/1516-4446-2019-0726
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author Peters, Renata B.
Xavier, Janaína
Mondin, Thaíse C.
Cardoso, Taiane de A.
Ferreira, Fabiana B.
Teixeira, Liana
Gräeff, Kiane
Quevedo, Luciana de A.
Jansen, Karen
Souza, Luciano D.
Oses, Jean P.
Pinheiro, Ricardo T.
da Silva, Ricardo A.
Ghisleni, Gabriele
author_facet Peters, Renata B.
Xavier, Janaína
Mondin, Thaíse C.
Cardoso, Taiane de A.
Ferreira, Fabiana B.
Teixeira, Liana
Gräeff, Kiane
Quevedo, Luciana de A.
Jansen, Karen
Souza, Luciano D.
Oses, Jean P.
Pinheiro, Ricardo T.
da Silva, Ricardo A.
Ghisleni, Gabriele
author_sort Peters, Renata B.
collection PubMed
description OBJECTIVE: Clinical and biological correlates of resilience in major depressive disorder are scarce. We aimed to investigate the effect of the Val(66)Met polymorphism in the BDNF gene on resilience scores in major depressive disorder patients and evaluate the polymorphism’s moderation effect on resilience scores in response to cognitive therapy. METHOD: A total of 106 major depressive disorder patients were enrolled in this clinical randomized study. The Resilience Scale and the Hamilton Rating Scale for Depression were applied at baseline, post-treatment, and at six months of follow-up. Blood samples were obtained at baseline for molecular analysis. RESULTS: The baseline resilience scores were higher in patients with the Met allele (114.6±17.6) than in those with the Val/Val genotype (104.04±21.05; p = 0.037). Cognitive therapy treatment increased resilience scores (p ≤ 0.001) and decreased depressive symptoms (p ≤ 0.001). In the mixed-effect model, the Val/Val genotype represented a decrease in resilience scores (t (218) = -1.98; p = 0.048), and the Val(66)Met polymorphism interacted with sex to predict an increase in total resilience scores during cognitive treatment (t (218) = 2.69; p = 0.008). CONCLUSION: Our results indicate that cognitive therapy intervention could improve resilience in follow-up, considering that gender and genetic susceptibility are predicted by the Val(66)Met polymorphism.
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spelling pubmed-78611812021-02-05 BDNF Val(66)Met polymorphism and resilience in major depressive disorder: the impact of cognitive psychotherapy Peters, Renata B. Xavier, Janaína Mondin, Thaíse C. Cardoso, Taiane de A. Ferreira, Fabiana B. Teixeira, Liana Gräeff, Kiane Quevedo, Luciana de A. Jansen, Karen Souza, Luciano D. Oses, Jean P. Pinheiro, Ricardo T. da Silva, Ricardo A. Ghisleni, Gabriele Braz J Psychiatry Original Article OBJECTIVE: Clinical and biological correlates of resilience in major depressive disorder are scarce. We aimed to investigate the effect of the Val(66)Met polymorphism in the BDNF gene on resilience scores in major depressive disorder patients and evaluate the polymorphism’s moderation effect on resilience scores in response to cognitive therapy. METHOD: A total of 106 major depressive disorder patients were enrolled in this clinical randomized study. The Resilience Scale and the Hamilton Rating Scale for Depression were applied at baseline, post-treatment, and at six months of follow-up. Blood samples were obtained at baseline for molecular analysis. RESULTS: The baseline resilience scores were higher in patients with the Met allele (114.6±17.6) than in those with the Val/Val genotype (104.04±21.05; p = 0.037). Cognitive therapy treatment increased resilience scores (p ≤ 0.001) and decreased depressive symptoms (p ≤ 0.001). In the mixed-effect model, the Val/Val genotype represented a decrease in resilience scores (t (218) = -1.98; p = 0.048), and the Val(66)Met polymorphism interacted with sex to predict an increase in total resilience scores during cognitive treatment (t (218) = 2.69; p = 0.008). CONCLUSION: Our results indicate that cognitive therapy intervention could improve resilience in follow-up, considering that gender and genetic susceptibility are predicted by the Val(66)Met polymorphism. Associação Brasileira de Psiquiatria 2020-08-21 /pmc/articles/PMC7861181/ /pubmed/32844885 http://dx.doi.org/10.1590/1516-4446-2019-0726 Text en http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Peters, Renata B.
Xavier, Janaína
Mondin, Thaíse C.
Cardoso, Taiane de A.
Ferreira, Fabiana B.
Teixeira, Liana
Gräeff, Kiane
Quevedo, Luciana de A.
Jansen, Karen
Souza, Luciano D.
Oses, Jean P.
Pinheiro, Ricardo T.
da Silva, Ricardo A.
Ghisleni, Gabriele
BDNF Val(66)Met polymorphism and resilience in major depressive disorder: the impact of cognitive psychotherapy
title BDNF Val(66)Met polymorphism and resilience in major depressive disorder: the impact of cognitive psychotherapy
title_full BDNF Val(66)Met polymorphism and resilience in major depressive disorder: the impact of cognitive psychotherapy
title_fullStr BDNF Val(66)Met polymorphism and resilience in major depressive disorder: the impact of cognitive psychotherapy
title_full_unstemmed BDNF Val(66)Met polymorphism and resilience in major depressive disorder: the impact of cognitive psychotherapy
title_short BDNF Val(66)Met polymorphism and resilience in major depressive disorder: the impact of cognitive psychotherapy
title_sort bdnf val(66)met polymorphism and resilience in major depressive disorder: the impact of cognitive psychotherapy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861181/
https://www.ncbi.nlm.nih.gov/pubmed/32844885
http://dx.doi.org/10.1590/1516-4446-2019-0726
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