Knockdown of Alpha-1 Antitrypsin with antisense oligonucleotide does not exacerbate smoke induced lung injury

Alpha-1 Antitrypsin (AAT) is a serum protease inhibitor that regulates increased lung protease production induced by cigarette smoking. Mutations in the Serpina1 gene cause AAT to form hepatoxic polymers, which can lead to reduced availability for the protein’s primary function and severe liver dise...

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Detalles Bibliográficos
Autores principales: Stearns, Kyle, Goldklang, Monica, Xiao, Rui, Zelonina, Tina, Blomenkamp, Keith, Teckman, Jeffery, D’Armiento, Jeanine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861354/
https://www.ncbi.nlm.nih.gov/pubmed/33539438
http://dx.doi.org/10.1371/journal.pone.0246040

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