Cargando…
Higher plasma drug levels in elderly people living with HIV treated with darunavir
BACKGROUND: The proportion of elderly people living with HIV-1 (PLHIV) is rising. In older patients, comorbidities and concomitant medications are more frequent, increasing the risk of potential drug-drug interactions (PDDIs). Data on the pharmacokinetics of ART in individuals aged ≥ 65 years of age...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861408/ https://www.ncbi.nlm.nih.gov/pubmed/33539440 http://dx.doi.org/10.1371/journal.pone.0246171 |
_version_ | 1783647081162866688 |
---|---|
author | Tyrberg, Erika Edén, Arvid Eriksen, Jaran Nilsson, Staffan Treutiger, Carl Johan Thalme, Anders Mellgren, Åsa Gisslén, Magnus Andersson, Lars-Magnus |
author_facet | Tyrberg, Erika Edén, Arvid Eriksen, Jaran Nilsson, Staffan Treutiger, Carl Johan Thalme, Anders Mellgren, Åsa Gisslén, Magnus Andersson, Lars-Magnus |
author_sort | Tyrberg, Erika |
collection | PubMed |
description | BACKGROUND: The proportion of elderly people living with HIV-1 (PLHIV) is rising. In older patients, comorbidities and concomitant medications are more frequent, increasing the risk of potential drug-drug interactions (PDDIs). Data on the pharmacokinetics of ART in individuals aged ≥ 65 years of age are scarce. We compared plasma drug levels of ART, PDDIs, and side-effects in PLHIV aged ≥ 65 years of age, with controls ≤ 49 years of age. METHODS: Patients ≥ 65 years of age and controls ≤ 49 years of age, all of whom were on stable treatment with atazanavir (ATV), darunavir (DRV), or efavirenz (EFV) were included cross-sectionally. Plasma drug levels of ART were analyzed, comorbidities, concomitant medication, adherence, and side-effects recorded, and PDDIs analyzed using drug interactions databases. RESULTS: Between 2013 and 2015, we included 100 individuals ≥ 65 years of age (study group) and 99 controls (≤ 49 years of age). Steady-state DRV concentrations were significantly higher in the study group than in the control group (p = 0.047). In the ATV group there was a trend towards a significant difference (p = 0.056). No significant differences were found in the EFV arm. The DRV arm had a higher frequency of reported side-effects than the ATV and EFV arms in the study group (36.7% vs. 0% and 23.8% respectively (p = 0.014), with significant differences between DRV vs. ATV, and EFV vs. ATV). CONCLUSIONS: Higher steady-state plasma levels of DRV and ATV (but not EFV) were found in PLHIV aged ≥ 65 years of age, compared to controls ≤ 49 years of age. |
format | Online Article Text |
id | pubmed-7861408 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-78614082021-02-12 Higher plasma drug levels in elderly people living with HIV treated with darunavir Tyrberg, Erika Edén, Arvid Eriksen, Jaran Nilsson, Staffan Treutiger, Carl Johan Thalme, Anders Mellgren, Åsa Gisslén, Magnus Andersson, Lars-Magnus PLoS One Research Article BACKGROUND: The proportion of elderly people living with HIV-1 (PLHIV) is rising. In older patients, comorbidities and concomitant medications are more frequent, increasing the risk of potential drug-drug interactions (PDDIs). Data on the pharmacokinetics of ART in individuals aged ≥ 65 years of age are scarce. We compared plasma drug levels of ART, PDDIs, and side-effects in PLHIV aged ≥ 65 years of age, with controls ≤ 49 years of age. METHODS: Patients ≥ 65 years of age and controls ≤ 49 years of age, all of whom were on stable treatment with atazanavir (ATV), darunavir (DRV), or efavirenz (EFV) were included cross-sectionally. Plasma drug levels of ART were analyzed, comorbidities, concomitant medication, adherence, and side-effects recorded, and PDDIs analyzed using drug interactions databases. RESULTS: Between 2013 and 2015, we included 100 individuals ≥ 65 years of age (study group) and 99 controls (≤ 49 years of age). Steady-state DRV concentrations were significantly higher in the study group than in the control group (p = 0.047). In the ATV group there was a trend towards a significant difference (p = 0.056). No significant differences were found in the EFV arm. The DRV arm had a higher frequency of reported side-effects than the ATV and EFV arms in the study group (36.7% vs. 0% and 23.8% respectively (p = 0.014), with significant differences between DRV vs. ATV, and EFV vs. ATV). CONCLUSIONS: Higher steady-state plasma levels of DRV and ATV (but not EFV) were found in PLHIV aged ≥ 65 years of age, compared to controls ≤ 49 years of age. Public Library of Science 2021-02-04 /pmc/articles/PMC7861408/ /pubmed/33539440 http://dx.doi.org/10.1371/journal.pone.0246171 Text en © 2021 Tyrberg et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Tyrberg, Erika Edén, Arvid Eriksen, Jaran Nilsson, Staffan Treutiger, Carl Johan Thalme, Anders Mellgren, Åsa Gisslén, Magnus Andersson, Lars-Magnus Higher plasma drug levels in elderly people living with HIV treated with darunavir |
title | Higher plasma drug levels in elderly people living with HIV treated with darunavir |
title_full | Higher plasma drug levels in elderly people living with HIV treated with darunavir |
title_fullStr | Higher plasma drug levels in elderly people living with HIV treated with darunavir |
title_full_unstemmed | Higher plasma drug levels in elderly people living with HIV treated with darunavir |
title_short | Higher plasma drug levels in elderly people living with HIV treated with darunavir |
title_sort | higher plasma drug levels in elderly people living with hiv treated with darunavir |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861408/ https://www.ncbi.nlm.nih.gov/pubmed/33539440 http://dx.doi.org/10.1371/journal.pone.0246171 |
work_keys_str_mv | AT tyrbergerika higherplasmadruglevelsinelderlypeoplelivingwithhivtreatedwithdarunavir AT edenarvid higherplasmadruglevelsinelderlypeoplelivingwithhivtreatedwithdarunavir AT eriksenjaran higherplasmadruglevelsinelderlypeoplelivingwithhivtreatedwithdarunavir AT nilssonstaffan higherplasmadruglevelsinelderlypeoplelivingwithhivtreatedwithdarunavir AT treutigercarljohan higherplasmadruglevelsinelderlypeoplelivingwithhivtreatedwithdarunavir AT thalmeanders higherplasmadruglevelsinelderlypeoplelivingwithhivtreatedwithdarunavir AT mellgrenasa higherplasmadruglevelsinelderlypeoplelivingwithhivtreatedwithdarunavir AT gisslenmagnus higherplasmadruglevelsinelderlypeoplelivingwithhivtreatedwithdarunavir AT anderssonlarsmagnus higherplasmadruglevelsinelderlypeoplelivingwithhivtreatedwithdarunavir |