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Three-dimensional chromatin in infectious disease—A role for gene regulation and pathogenicity?

The recent Coronavirus Disease 2019 pandemic has once again reminded us the importance of understanding infectious diseases. One important but understudied area in infectious disease research is the role of nuclear architecture or the physical arrangement of the genome in the nucleus in controlling...

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Autores principales: Davis, Sage Z., Hollin, Thomas, Lenz, Todd, Le Roch, Karine G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861443/
https://www.ncbi.nlm.nih.gov/pubmed/33539484
http://dx.doi.org/10.1371/journal.ppat.1009207
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author Davis, Sage Z.
Hollin, Thomas
Lenz, Todd
Le Roch, Karine G.
author_facet Davis, Sage Z.
Hollin, Thomas
Lenz, Todd
Le Roch, Karine G.
author_sort Davis, Sage Z.
collection PubMed
description The recent Coronavirus Disease 2019 pandemic has once again reminded us the importance of understanding infectious diseases. One important but understudied area in infectious disease research is the role of nuclear architecture or the physical arrangement of the genome in the nucleus in controlling gene regulation and pathogenicity. Recent advances in research methods, such as Genome-wide chromosome conformation capture using high-throughput sequencing (Hi-C), have allowed for easier analysis of nuclear architecture and chromosomal reorganization in both the infectious disease agents themselves as well as in their host cells. This review will discuss broadly on what is known about nuclear architecture in infectious disease, with an emphasis on chromosomal reorganization, and briefly discuss what steps are required next in the field.
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spelling pubmed-78614432021-02-12 Three-dimensional chromatin in infectious disease—A role for gene regulation and pathogenicity? Davis, Sage Z. Hollin, Thomas Lenz, Todd Le Roch, Karine G. PLoS Pathog Review The recent Coronavirus Disease 2019 pandemic has once again reminded us the importance of understanding infectious diseases. One important but understudied area in infectious disease research is the role of nuclear architecture or the physical arrangement of the genome in the nucleus in controlling gene regulation and pathogenicity. Recent advances in research methods, such as Genome-wide chromosome conformation capture using high-throughput sequencing (Hi-C), have allowed for easier analysis of nuclear architecture and chromosomal reorganization in both the infectious disease agents themselves as well as in their host cells. This review will discuss broadly on what is known about nuclear architecture in infectious disease, with an emphasis on chromosomal reorganization, and briefly discuss what steps are required next in the field. Public Library of Science 2021-02-04 /pmc/articles/PMC7861443/ /pubmed/33539484 http://dx.doi.org/10.1371/journal.ppat.1009207 Text en © 2021 Davis et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Davis, Sage Z.
Hollin, Thomas
Lenz, Todd
Le Roch, Karine G.
Three-dimensional chromatin in infectious disease—A role for gene regulation and pathogenicity?
title Three-dimensional chromatin in infectious disease—A role for gene regulation and pathogenicity?
title_full Three-dimensional chromatin in infectious disease—A role for gene regulation and pathogenicity?
title_fullStr Three-dimensional chromatin in infectious disease—A role for gene regulation and pathogenicity?
title_full_unstemmed Three-dimensional chromatin in infectious disease—A role for gene regulation and pathogenicity?
title_short Three-dimensional chromatin in infectious disease—A role for gene regulation and pathogenicity?
title_sort three-dimensional chromatin in infectious disease—a role for gene regulation and pathogenicity?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861443/
https://www.ncbi.nlm.nih.gov/pubmed/33539484
http://dx.doi.org/10.1371/journal.ppat.1009207
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