Cargando…

Relationship of common hemodynamic and respiratory target parameters with brain tissue oxygen tension in the absence of hypoxemia or hypotension after cardiac arrest: A post-hoc analysis of an experimental study using a pig model

Brain tissue oxygen tension (PbtO(2))-guided care, a therapeutic strategy to treat or prevent cerebral hypoxia through modifying determinants of cerebral oxygen delivery, including arterial oxygen tension (PaO(2)), end-tidal carbon dioxide (ETCO(2)), and mean arterial pressure (MAP), has recently be...

Descripción completa

Detalles Bibliográficos
Autores principales: Jung, Yong Hun, Shamsiev, Kamoljon, Mamadjonov, Najmiddin, Jeung, Kyung Woon, Lee, Hyoung Youn, Lee, Byung Kook, Kang, Byung Soo, Heo, Tag, Min, Yong Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861448/
https://www.ncbi.nlm.nih.gov/pubmed/33539360
http://dx.doi.org/10.1371/journal.pone.0245931
_version_ 1783647090538184704
author Jung, Yong Hun
Shamsiev, Kamoljon
Mamadjonov, Najmiddin
Jeung, Kyung Woon
Lee, Hyoung Youn
Lee, Byung Kook
Kang, Byung Soo
Heo, Tag
Min, Yong Il
author_facet Jung, Yong Hun
Shamsiev, Kamoljon
Mamadjonov, Najmiddin
Jeung, Kyung Woon
Lee, Hyoung Youn
Lee, Byung Kook
Kang, Byung Soo
Heo, Tag
Min, Yong Il
author_sort Jung, Yong Hun
collection PubMed
description Brain tissue oxygen tension (PbtO(2))-guided care, a therapeutic strategy to treat or prevent cerebral hypoxia through modifying determinants of cerebral oxygen delivery, including arterial oxygen tension (PaO(2)), end-tidal carbon dioxide (ETCO(2)), and mean arterial pressure (MAP), has recently been introduced. Studies have reported that cerebral hypoxia occurs after cardiac arrest in the absence of hypoxemia or hypotension. To obtain preliminary information on the degree to which PbtO(2) is responsive to changes in the common target variables for PbtO(2)-guided care in conditions without hypoxemia or hypotension, we investigated the relationships between the common target variables for PbtO(2)-guided care and PbtO(2) using data from an experimental study in which the animals did not experience hypoxemia or hypotension after resuscitation. We retrospectively analyzed 170 sets of MAP, ETCO(2), PaO(2), PbtO(2), and cerebral microcirculation parameters obtained during the 60-min post-resuscitation period in 10 pigs resuscitated from ventricular fibrillation cardiac arrest. PbtO(2) and cerebral microcirculation parameters were measured on parietal cortices exposed through burr holes. Multiple linear mixed effect models were used to test the independent effects of each variable on PbtO(2). Despite the absence of arterial hypoxemia or hypotension, seven (70%) animals experienced cerebral hypoxia (defined as PbtO(2) <20 mmHg). Linear mixed effect models revealed that neither MAP nor ETCO(2) were related to PbtO(2). PaO(2) had a significant linear relationship with PbtO(2) after adjusting for significant covariates (P = 0.030), but it could explain only 17.5% of the total PbtO(2) variance (semi-partial R(2) = 0.175; 95% confidence interval, 0.086–0.282). In conclusion, MAP and ETCO(2) were not significantly related to PbtO(2) in animals without hypoxemia or hypotension during the early post-resuscitation period. PaO(2) had a significant linear association with PbtO(2), but its ability to explain PbtO(2) variance was small.
format Online
Article
Text
id pubmed-7861448
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-78614482021-02-12 Relationship of common hemodynamic and respiratory target parameters with brain tissue oxygen tension in the absence of hypoxemia or hypotension after cardiac arrest: A post-hoc analysis of an experimental study using a pig model Jung, Yong Hun Shamsiev, Kamoljon Mamadjonov, Najmiddin Jeung, Kyung Woon Lee, Hyoung Youn Lee, Byung Kook Kang, Byung Soo Heo, Tag Min, Yong Il PLoS One Research Article Brain tissue oxygen tension (PbtO(2))-guided care, a therapeutic strategy to treat or prevent cerebral hypoxia through modifying determinants of cerebral oxygen delivery, including arterial oxygen tension (PaO(2)), end-tidal carbon dioxide (ETCO(2)), and mean arterial pressure (MAP), has recently been introduced. Studies have reported that cerebral hypoxia occurs after cardiac arrest in the absence of hypoxemia or hypotension. To obtain preliminary information on the degree to which PbtO(2) is responsive to changes in the common target variables for PbtO(2)-guided care in conditions without hypoxemia or hypotension, we investigated the relationships between the common target variables for PbtO(2)-guided care and PbtO(2) using data from an experimental study in which the animals did not experience hypoxemia or hypotension after resuscitation. We retrospectively analyzed 170 sets of MAP, ETCO(2), PaO(2), PbtO(2), and cerebral microcirculation parameters obtained during the 60-min post-resuscitation period in 10 pigs resuscitated from ventricular fibrillation cardiac arrest. PbtO(2) and cerebral microcirculation parameters were measured on parietal cortices exposed through burr holes. Multiple linear mixed effect models were used to test the independent effects of each variable on PbtO(2). Despite the absence of arterial hypoxemia or hypotension, seven (70%) animals experienced cerebral hypoxia (defined as PbtO(2) <20 mmHg). Linear mixed effect models revealed that neither MAP nor ETCO(2) were related to PbtO(2). PaO(2) had a significant linear relationship with PbtO(2) after adjusting for significant covariates (P = 0.030), but it could explain only 17.5% of the total PbtO(2) variance (semi-partial R(2) = 0.175; 95% confidence interval, 0.086–0.282). In conclusion, MAP and ETCO(2) were not significantly related to PbtO(2) in animals without hypoxemia or hypotension during the early post-resuscitation period. PaO(2) had a significant linear association with PbtO(2), but its ability to explain PbtO(2) variance was small. Public Library of Science 2021-02-04 /pmc/articles/PMC7861448/ /pubmed/33539360 http://dx.doi.org/10.1371/journal.pone.0245931 Text en © 2021 Jung et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Jung, Yong Hun
Shamsiev, Kamoljon
Mamadjonov, Najmiddin
Jeung, Kyung Woon
Lee, Hyoung Youn
Lee, Byung Kook
Kang, Byung Soo
Heo, Tag
Min, Yong Il
Relationship of common hemodynamic and respiratory target parameters with brain tissue oxygen tension in the absence of hypoxemia or hypotension after cardiac arrest: A post-hoc analysis of an experimental study using a pig model
title Relationship of common hemodynamic and respiratory target parameters with brain tissue oxygen tension in the absence of hypoxemia or hypotension after cardiac arrest: A post-hoc analysis of an experimental study using a pig model
title_full Relationship of common hemodynamic and respiratory target parameters with brain tissue oxygen tension in the absence of hypoxemia or hypotension after cardiac arrest: A post-hoc analysis of an experimental study using a pig model
title_fullStr Relationship of common hemodynamic and respiratory target parameters with brain tissue oxygen tension in the absence of hypoxemia or hypotension after cardiac arrest: A post-hoc analysis of an experimental study using a pig model
title_full_unstemmed Relationship of common hemodynamic and respiratory target parameters with brain tissue oxygen tension in the absence of hypoxemia or hypotension after cardiac arrest: A post-hoc analysis of an experimental study using a pig model
title_short Relationship of common hemodynamic and respiratory target parameters with brain tissue oxygen tension in the absence of hypoxemia or hypotension after cardiac arrest: A post-hoc analysis of an experimental study using a pig model
title_sort relationship of common hemodynamic and respiratory target parameters with brain tissue oxygen tension in the absence of hypoxemia or hypotension after cardiac arrest: a post-hoc analysis of an experimental study using a pig model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861448/
https://www.ncbi.nlm.nih.gov/pubmed/33539360
http://dx.doi.org/10.1371/journal.pone.0245931
work_keys_str_mv AT jungyonghun relationshipofcommonhemodynamicandrespiratorytargetparameterswithbraintissueoxygentensionintheabsenceofhypoxemiaorhypotensionaftercardiacarrestaposthocanalysisofanexperimentalstudyusingapigmodel
AT shamsievkamoljon relationshipofcommonhemodynamicandrespiratorytargetparameterswithbraintissueoxygentensionintheabsenceofhypoxemiaorhypotensionaftercardiacarrestaposthocanalysisofanexperimentalstudyusingapigmodel
AT mamadjonovnajmiddin relationshipofcommonhemodynamicandrespiratorytargetparameterswithbraintissueoxygentensionintheabsenceofhypoxemiaorhypotensionaftercardiacarrestaposthocanalysisofanexperimentalstudyusingapigmodel
AT jeungkyungwoon relationshipofcommonhemodynamicandrespiratorytargetparameterswithbraintissueoxygentensionintheabsenceofhypoxemiaorhypotensionaftercardiacarrestaposthocanalysisofanexperimentalstudyusingapigmodel
AT leehyoungyoun relationshipofcommonhemodynamicandrespiratorytargetparameterswithbraintissueoxygentensionintheabsenceofhypoxemiaorhypotensionaftercardiacarrestaposthocanalysisofanexperimentalstudyusingapigmodel
AT leebyungkook relationshipofcommonhemodynamicandrespiratorytargetparameterswithbraintissueoxygentensionintheabsenceofhypoxemiaorhypotensionaftercardiacarrestaposthocanalysisofanexperimentalstudyusingapigmodel
AT kangbyungsoo relationshipofcommonhemodynamicandrespiratorytargetparameterswithbraintissueoxygentensionintheabsenceofhypoxemiaorhypotensionaftercardiacarrestaposthocanalysisofanexperimentalstudyusingapigmodel
AT heotag relationshipofcommonhemodynamicandrespiratorytargetparameterswithbraintissueoxygentensionintheabsenceofhypoxemiaorhypotensionaftercardiacarrestaposthocanalysisofanexperimentalstudyusingapigmodel
AT minyongil relationshipofcommonhemodynamicandrespiratorytargetparameterswithbraintissueoxygentensionintheabsenceofhypoxemiaorhypotensionaftercardiacarrestaposthocanalysisofanexperimentalstudyusingapigmodel