Cargando…
Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion
Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infects cells by binding to the host cell receptor ACE2 and undergoing virus-host membrane fusion. Fusion is triggered by the protease TMPRSS2, which processes the viral Spike (S) protein to reveal the fusion peptide. SARS-CoV-2 has evolve...
Autores principales: | Papa, Guido, Mallery, Donna L., Albecka, Anna, Welch, Lawrence G., Cattin-Ortolá, Jérôme, Luptak, Jakub, Paul, David, McMahon, Harvey T., Goodfellow, Ian G., Carter, Andrew, Munro, Sean, James, Leo C. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861537/ https://www.ncbi.nlm.nih.gov/pubmed/33493182 http://dx.doi.org/10.1371/journal.ppat.1009246 |
Ejemplares similares
-
Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation
por: Cattin-Ortolá, Jérôme, et al.
Publicado: (2021) -
TRIM7 Restricts Coxsackievirus and Norovirus Infection by Detecting the C-Terminal Glutamine Generated by 3C Protease Processing
por: Luptak, Jakub, et al.
Publicado: (2022) -
The Emergence of the Spike Furin Cleavage Site in SARS-CoV-2
por: Chan, Yujia Alina, et al.
Publicado: (2021) -
Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation
por: Zhang, Liping, et al.
Publicado: (2021) -
Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation
por: Zhang, Liping, et al.
Publicado: (2021)