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Post-lockdown abatement of COVID-19 by fast periodic switching

COVID-19 abatement strategies have risks and uncertainties which could lead to repeating waves of infection. We show—as proof of concept grounded on rigorous mathematical evidence—that periodic, high-frequency alternation of into, and out-of, lockdown effectively mitigates second-wave effects, while...

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Autores principales: Bin, Michelangelo, Cheung, Peter Y. K., Crisostomi, Emanuele, Ferraro, Pietro, Lhachemi, Hugo, Murray-Smith, Roderick, Myant, Connor, Parisini, Thomas, Shorten, Robert, Stein, Sebastian, Stone, Lewi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861565/
https://www.ncbi.nlm.nih.gov/pubmed/33476332
http://dx.doi.org/10.1371/journal.pcbi.1008604
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author Bin, Michelangelo
Cheung, Peter Y. K.
Crisostomi, Emanuele
Ferraro, Pietro
Lhachemi, Hugo
Murray-Smith, Roderick
Myant, Connor
Parisini, Thomas
Shorten, Robert
Stein, Sebastian
Stone, Lewi
author_facet Bin, Michelangelo
Cheung, Peter Y. K.
Crisostomi, Emanuele
Ferraro, Pietro
Lhachemi, Hugo
Murray-Smith, Roderick
Myant, Connor
Parisini, Thomas
Shorten, Robert
Stein, Sebastian
Stone, Lewi
author_sort Bin, Michelangelo
collection PubMed
description COVID-19 abatement strategies have risks and uncertainties which could lead to repeating waves of infection. We show—as proof of concept grounded on rigorous mathematical evidence—that periodic, high-frequency alternation of into, and out-of, lockdown effectively mitigates second-wave effects, while allowing continued, albeit reduced, economic activity. Periodicity confers (i) predictability, which is essential for economic sustainability, and (ii) robustness, since lockdown periods are not activated by uncertain measurements over short time scales. In turn—while not eliminating the virus—this fast switching policy is sustainable over time, and it mitigates the infection until a vaccine or treatment becomes available, while alleviating the social costs associated with long lockdowns. Typically, the policy might be in the form of 1-day of work followed by 6-days of lockdown every week (or perhaps 2 days working, 5 days off) and it can be modified at a slow-rate based on measurements filtered over longer time scales. Our results highlight the potential efficacy of high frequency switching interventions in post lockdown mitigation. All code is available on Github at https://github.com/V4p1d/FPSP_Covid19. A software tool has also been developed so that interested parties can explore the proof-of-concept system.
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spelling pubmed-78615652021-02-12 Post-lockdown abatement of COVID-19 by fast periodic switching Bin, Michelangelo Cheung, Peter Y. K. Crisostomi, Emanuele Ferraro, Pietro Lhachemi, Hugo Murray-Smith, Roderick Myant, Connor Parisini, Thomas Shorten, Robert Stein, Sebastian Stone, Lewi PLoS Comput Biol Research Article COVID-19 abatement strategies have risks and uncertainties which could lead to repeating waves of infection. We show—as proof of concept grounded on rigorous mathematical evidence—that periodic, high-frequency alternation of into, and out-of, lockdown effectively mitigates second-wave effects, while allowing continued, albeit reduced, economic activity. Periodicity confers (i) predictability, which is essential for economic sustainability, and (ii) robustness, since lockdown periods are not activated by uncertain measurements over short time scales. In turn—while not eliminating the virus—this fast switching policy is sustainable over time, and it mitigates the infection until a vaccine or treatment becomes available, while alleviating the social costs associated with long lockdowns. Typically, the policy might be in the form of 1-day of work followed by 6-days of lockdown every week (or perhaps 2 days working, 5 days off) and it can be modified at a slow-rate based on measurements filtered over longer time scales. Our results highlight the potential efficacy of high frequency switching interventions in post lockdown mitigation. All code is available on Github at https://github.com/V4p1d/FPSP_Covid19. A software tool has also been developed so that interested parties can explore the proof-of-concept system. Public Library of Science 2021-01-21 /pmc/articles/PMC7861565/ /pubmed/33476332 http://dx.doi.org/10.1371/journal.pcbi.1008604 Text en © 2021 Bin et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Bin, Michelangelo
Cheung, Peter Y. K.
Crisostomi, Emanuele
Ferraro, Pietro
Lhachemi, Hugo
Murray-Smith, Roderick
Myant, Connor
Parisini, Thomas
Shorten, Robert
Stein, Sebastian
Stone, Lewi
Post-lockdown abatement of COVID-19 by fast periodic switching
title Post-lockdown abatement of COVID-19 by fast periodic switching
title_full Post-lockdown abatement of COVID-19 by fast periodic switching
title_fullStr Post-lockdown abatement of COVID-19 by fast periodic switching
title_full_unstemmed Post-lockdown abatement of COVID-19 by fast periodic switching
title_short Post-lockdown abatement of COVID-19 by fast periodic switching
title_sort post-lockdown abatement of covid-19 by fast periodic switching
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861565/
https://www.ncbi.nlm.nih.gov/pubmed/33476332
http://dx.doi.org/10.1371/journal.pcbi.1008604
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