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Capillary leak syndrome and disseminated intravascular coagulation after kidney transplantation in a patient with hereditary angioedema - A case report -
BACKGROUND: Hereditary angioedema (HAE) is a rare disease caused by the deficiency of C1 esterase inhibitor. HAE has a risk of life-threatening complications such as capillary leak syndrome (CLS) and disseminated intravascular coagulation (DIC). CASE: A 42-year-old male patient with HAE presented fo...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Anesthesiologists
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861902/ https://www.ncbi.nlm.nih.gov/pubmed/33530679 http://dx.doi.org/10.17085/apm.20098 |
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author | Park, Jeong Wook Seo, Jinyoung Kim, Sang Hun Jung, Ki Tae |
author_facet | Park, Jeong Wook Seo, Jinyoung Kim, Sang Hun Jung, Ki Tae |
author_sort | Park, Jeong Wook |
collection | PubMed |
description | BACKGROUND: Hereditary angioedema (HAE) is a rare disease caused by the deficiency of C1 esterase inhibitor. HAE has a risk of life-threatening complications such as capillary leak syndrome (CLS) and disseminated intravascular coagulation (DIC). CASE: A 42-year-old male patient with HAE presented for deceased-donor kidney transplantation. Prophylactic fresh frozen plasma (FFP) was given before surgery because of the risk of edema development. With careful management during anesthesia, there were no problems during surgery. However, generalized edema, hypotension, hypoalbuminemia, massive drainage of serosanguineous fluids from the intraabdominal space, and DIC occurred on the day after surgery. CLS was suspected and sustained hypotension with generalized edema became worse despite treatment with albumin, danazol, FFP, and vasoactive drugs. The patient’s condition worsened despite intensive care and he died due to shock. CONCLUSIONS: The anesthesiologist should prepare for the critical complications of HAE and prepare the appropriate treatment options. |
format | Online Article Text |
id | pubmed-7861902 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Korean Society of Anesthesiologists |
record_format | MEDLINE/PubMed |
spelling | pubmed-78619022021-02-10 Capillary leak syndrome and disseminated intravascular coagulation after kidney transplantation in a patient with hereditary angioedema - A case report - Park, Jeong Wook Seo, Jinyoung Kim, Sang Hun Jung, Ki Tae Anesth Pain Med (Seoul) Transplantation Anesthesia BACKGROUND: Hereditary angioedema (HAE) is a rare disease caused by the deficiency of C1 esterase inhibitor. HAE has a risk of life-threatening complications such as capillary leak syndrome (CLS) and disseminated intravascular coagulation (DIC). CASE: A 42-year-old male patient with HAE presented for deceased-donor kidney transplantation. Prophylactic fresh frozen plasma (FFP) was given before surgery because of the risk of edema development. With careful management during anesthesia, there were no problems during surgery. However, generalized edema, hypotension, hypoalbuminemia, massive drainage of serosanguineous fluids from the intraabdominal space, and DIC occurred on the day after surgery. CLS was suspected and sustained hypotension with generalized edema became worse despite treatment with albumin, danazol, FFP, and vasoactive drugs. The patient’s condition worsened despite intensive care and he died due to shock. CONCLUSIONS: The anesthesiologist should prepare for the critical complications of HAE and prepare the appropriate treatment options. Korean Society of Anesthesiologists 2021-01-31 2021-01-27 /pmc/articles/PMC7861902/ /pubmed/33530679 http://dx.doi.org/10.17085/apm.20098 Text en Copyright © the Korean Society of Anesthesiologists, 2021 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Transplantation Anesthesia Park, Jeong Wook Seo, Jinyoung Kim, Sang Hun Jung, Ki Tae Capillary leak syndrome and disseminated intravascular coagulation after kidney transplantation in a patient with hereditary angioedema - A case report - |
title | Capillary leak syndrome and disseminated intravascular coagulation after kidney transplantation in a patient with hereditary angioedema - A case report - |
title_full | Capillary leak syndrome and disseminated intravascular coagulation after kidney transplantation in a patient with hereditary angioedema - A case report - |
title_fullStr | Capillary leak syndrome and disseminated intravascular coagulation after kidney transplantation in a patient with hereditary angioedema - A case report - |
title_full_unstemmed | Capillary leak syndrome and disseminated intravascular coagulation after kidney transplantation in a patient with hereditary angioedema - A case report - |
title_short | Capillary leak syndrome and disseminated intravascular coagulation after kidney transplantation in a patient with hereditary angioedema - A case report - |
title_sort | capillary leak syndrome and disseminated intravascular coagulation after kidney transplantation in a patient with hereditary angioedema - a case report - |
topic | Transplantation Anesthesia |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861902/ https://www.ncbi.nlm.nih.gov/pubmed/33530679 http://dx.doi.org/10.17085/apm.20098 |
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